Metronidazole and tinidazole – It’s best to completely avoid alcohol while taking:
metronidazole – an antibiotic sometimes used for dental or vaginal infections, skin infections, infected leg ulcers and pressure sorestinidazole – an antibiotic sometimes used to treat many of the same infections as metronidazole, as well as to help clear bacteria called Helicobacter pylori (H. pylori) from the gut
Continue to avoid alcohol for 48 hours after you stop taking metronidazole and 72 hours after you stop taking tinidazole. Drinking alcohol with metronidazole or tinidazole can cause very unpleasant side effects, such as:
feeling and being sickstomach painhot flushesa fast or irregular heartbeatheadachesfeeling dizzyfeeling drowsy
What happens if I have a glass of wine with metronidazole?
The potential interactions of antimicrobials with alcohol are best considered in three categories, all of which have patient implications: (i) alterations in pharmacokinetics and pharmacodynamics (PK/PD) of the antimicrobial and/or alcohol, (ii) changes in antimicrobial efficacy, and (iii) development of toxicity.
- PK/PD were considered together to describe the effect of drug and alcohol on absorption, distribution, metabolism, and excretion (PK) and the resultant effect of this interaction on the host (PD).
- Concomitant use of alcohol with antimicrobials is believed to either decrease efficacy or lead to toxicity/ADR ( 6, 7 ).
The classic example of a feared medication interaction with alcohol is the “disulfiram-like” reaction. Symptoms may include facial flushing, nausea, headache, vomiting, chest pain, vertigo, sweating, thirst, blurred vision, weakness, confusion, and hypotension ( 8 ).
Furthermore, alcohol can cause hepatic stress or injury with or without the use of potentially hepatotoxic medications. These concerns may be responsible for alcohol warnings that accompany many antimicrobials, but what are the data and strength of support for these warnings? The goal of this review was to summarize existing data, which in turn generates insights into the origin of these warnings.
This review may also be helpful in assessing a patient who presents with an adverse drug effect which may or may not have been due to an alcohol and antibiotic interaction. Although we do not want to encourage alcohol use, it is important for health care professionals to be informed on this common clinical scenario, ensuring that patients can be educated and questions can be addressed in an evidence-based manner.
Has anyone had alcohol with metronidazole?
Drinking alcohol while taking metronidazole is not recommended because the combination of metronidazole and alcohol can cause a reaction (often referred to as a disulfiram-like reaction) in some people. Symptoms may include flushing, headaches, nausea, vomiting, and stomach cramps.
- There has been one reported death associated with this reaction.
- The product information and health professionals recommend not to drink alcohol during metronidazole treatment and for 3 days after finishing the course.
- However, there is controversy around this reaction because while some studies have shown serious problems for some people taking metronidazole, others have shown the combination does not cause any problems.
Large clinical trials in humans have never been conducted to confirm this interaction. The reaction has been referred to as a disulfiram-like reaction – disulfiram is a medication given to people to discourage alcohol consumption. When a person consumes alcohol, the body breaks it down in two steps.
- First, it breaks alcohol down into a compound called acetaldehyde.
- Acetaldehyde is responsible for the unwanted effects of alcohol such as nausea, vomiting, and flushing, and is toxic.
- Next, the body reduces acetaldehyde to acetate using an enzyme called aldehyde dehydrogenase.
- Acetate is easily oxidized by our body into carbon dioxide (CO2), which we then breathe out.
Disulfiram blocks the effects of this enzyme which leads to acetaldehyde accumulation causing symptoms such as skin redness, palpitations, nausea, vomiting, headache and in severe cases a dangerous rapid heart rate or a sudden drop in blood pressure.
It was thought that metronidazole blocked the enzyme aldehyde dehydrogenase as well, although this now seems to be incorrect. Several studies that have investigated the reaction of metronidazole with alcohol have found evidence of the existence of this interaction to be absent or weak. It does seems that the concern attached to this reaction is overstated.
It is possible that the reaction could just be a side effect of metronidazole or potentially only occur in a small sub-group of susceptible people, because the reaction does not appear to occur in everybody. There needs to be more research done investigating this potential interaction, but because doctors are unable to say which people are more at risk of this interaction, it is best to err on the side of caution and avoid alcohol while taking metronidazole until more is known.
How long can you not drink on antibiotics?
What to do – The warning label on your antibiotic should include information about alcohol use. Talk to your doctor or pharmacist if you’re unsure about the details of your medications. They may tell you that an occasional drink is OK. But that likely depends on your age, overall health, and the type of drug you’re taking.
Can I drink 24 hours after metronidazole?
So can you have a drink as soon as you’ve finished a course of metronidazole or tinidazole? – It’s actually best not to as these antibiotics may still interact with alcohol several hours after completing your course. You should avoid drinking alcohol for at least 24 hours after finishing a prescribed course of metronidazole, and at least 72 hours after finishing a prescribed course of tinidazole.
How long do metronidazole side effects last?
More common side effects – The more common side effects that can occur with metronidazole vaginal gel are generally mild. They can include:
vaginal yeast infectionvaginal itchingheadachenauseavomitingmenstrual cramps
Can metronidazole make you sleepy?
While taking Metronidazole Tablet you may feel sleepy, dizzy, confused, see or hear things that are not there (hallucinations), have fits (convulsions) or temporary eyesight problems (such as blurred or double vision). If this happens, do not drive or use any machinery or tools.