Side Effects – TUDCA is very well tolerated and most users experience no side effects from supplementing at the recommended 500 mg dose. Diarrhea has occasionally been reported in some users taking over 1000 mg of TUDCA per day. TUDCA should not be taken before drinking alcohol as the combination of alcohol and TUDCA may be more damaging to the liver than alcohol alone.
Contents
- 1 How much TUDCA should I take for liver?
- 2 How much TUDCA per day for liver repair?
- 3 Can I drink alcohol after 3 hours of taking medicine?
- 4 Can I drink while taking TUDCA?
- 5 What to expect after taking TUDCA?
- 6 What does TUDCA do to the brain?
- 7 Does TUDCA cause detox?
- 8 How many days does it take to rejuvenate your liver?
- 9 Does TUDCA reduce inflammation?
- 10 Can you take supplements before drinking alcohol?
- 11 What does TUDCA interact with?
- 12 Does TUDCA detox the liver?
- 13 Can I take NAC supplement before alcohol?
Can you take TUDCA before drinking alcohol?
Caution: Do not take TUDCA before binging on alcohol. It will make liver damage worse.
How long does TUDCA take to work?
TUDCA (Tauroursodeoxycholic Acid) Supplement’s Role in the Body – TUDCA is a bile acid naturally formed in the body that supports the digestion and utilization of fats and oils and demonstrates neuroprotective benefits*. TUDCA supports digestive ability by supporting healthy fat metabolism and breakdown as well as proper nutrient absorption.
- It is also supportive to cellular and mitochondrial health.
- However, the human body only produces small amounts of TUDCA (or tauroursodeoxycholic acid).
- In a healthy person, digestion re-circulates some 95% of the body’s bile salts.
- Poor diet, decreased liver function, and certain medications can impair this process.
This is where supplementation is key. read more Why Buy BodyBio TUDCA? Quality matters. We don’t use fillers or additives. There is no way to achieve the powerful benefits of Tudca without strict internal and external quality control. The raw materials of BodyBio Tudca undergo extensive testing for the presence of mold prior to encapsulation.
Supports the digestion of fats and oils*Promotes a healthy microbiome with healthy biodiversity*Supports a healthy inflammation response in the GI tract to help prevent leaky gut*Helps reduce cellular stress & protect DNA*May address fatty liver, biliary cirrhosis and hepatitis*May be effective in supporting neurological concerns*Assists in clearing toxins* Stabilizes the cell membrane*Works with other bile salts to prevent premature cell death (apoptosis)* Eases stress on the endoplasmic reticulum (ER) to improve protein folding*May provide neuroprotective benefits.*May help regulate the immune system*May affect genetic expression and mitochondria*May dissolve gallstones before they are completely formed*May cause liver and muscle to be more sensitive to insulin (High insulin sensitivity helps cells use blood glucose more effectively, which can help reduce blood sugar.)*
read more Specifically formulated to:
Support digestion*Support the liver*Neuroprotective support*
read more Ingredients Tauroursodeoxycholic acid, rice flour, gelatin (capsules) read more Suggested Use 1-2 capsules with food, unless otherwise directed by your healthcare professional. read more Supports intracellular cholesterol (which you cannot feel but it’s good to know)! Aids in digesting fats and helps support healthy bile blow.* You may notice that taking after high fat meals helps with digestion.
Supports insulin sensitivity, increased liver function, & promotes the growth of healthy bacteria in the microbiome for decreased inflammation.* Brain support – TUDCA works as a “chaperone” to interrupt protein misfolding to overcome neurological concerns.* If you’re wondering about when to take TUDCA, we recommend one to three times daily with meals.
It may be taken with or without food. We recommend taking it with food to support absorption. If your gallbladder has been removed, taking it with food may aid in digestion. Research shows TUDCA’s benefits occur anywhere from one to six months of daily use.
The suggested dosage is take 2 capsules per day or use as directed by your Healthcare Professional.1750 mg is the tolerable upper limit for most and can be used as a therapeutic dose for as long as one month. TUDCA is suitable for those without a gallbladder. TUDCA supplements are generally considered safe when taken in the recommended amounts.
Some have experienced diarrhea when taking more than 1500 mg daily, which is not recommended. There are no other reported TUDCA side effects. Research shows TUDCA’s benefits occur anywhere from one to six months of daily use. BodyBio’s TUDCA is not derived from bear bile, bull bile, or the bile of other animals. We manufacture and rigorously test quality at our New Jersey HQ We carefully source the highest quality raw materials for our products – never oxidized or heat treated For over 25-years BodyBio has remained a family business. It’s why we treat our customers like family and why thousands of doctors trust us with their patient’s health
How much TUDCA should I take for liver?
When looking at improving bile salt composition, a dose around 15-20mg/kg bodyweight TUDCA seems best according to one study. Benefits have been seen at 1,750mg daily for muscle and liver insulin sensitivity, which is the highest dose used for treatment of fatty liver disease.
How much TUDCA per day for liver repair?
People Also Asked – Q: What are the main benefits of TUDCA supplements? A: TUDCA (Tauroursodeoxycholic Acid) supplements offer a variety of health benefits, primarily focusing on liver health and protection. As a potent bile acid, TUDCA supports healthy bile flow, which aids in detoxification and digestion, reducing the risk of gallstones and liver diseases.
Furthermore, TUDCA’s anti-inflammatory and antioxidant properties may help combat conditions like non-alcoholic fatty liver disease and cholestasis while also providing neuroprotective effects for those with neurodegenerative disorders like Parkinson’s and Alzheimer’s. Additionally, TUDCA may link to improved insulin sensitivity — which is especially beneficial for diabetic patients.
Q: What is the proper dosage for TUDCA supplements? A: The proper dosage of TUDCA supplements depends on the individual and can vary depending on age, weight, health condition, and desired outcome. Generally, the recommended dosage for people with liver disorders is 1000 mg daily, taken in two doses of 500 mg each.
It’s essential to start with a lower dose and adjust it according to your body’s response. For example, if you’re taking TUDCA for hepatitis C, don’t take more than 1000 mg daily. If you experience any side effects like nausea or stomach pain, reduce the dosage to 250 mg daily and then increase it gradually until you find the right amount that works for your body.
Q: Are there any potential side effects of taking TUDCA supplements? A: Common side effects of taking TUDCA supplements include upset stomach, nausea, vomiting, and diarrhea. It is important to consult a healthcare practitioner before taking any new supplement or medication to avoid adverse reactions.
- Q: Should I take my TUDCA supplements on an empty stomach or with food? A: Tudca should be taken with food to maximize its absorption and reduce the risk of any gastrointestinal side effects.
- It is especially true if taken in large doses, as its absorption may be affected by the lack of food in the stomach.
Q: How long does it take to see results from taking TUDCA supplements? A: It typically takes two to three weeks of consistently taking TUDCA to see positive results such as improved liver function, reduced inflammation, increased energy levels, and improved digestion. Jessica Day is a Las Vegas-based commerce writer with over 5 years of experience in writing. As a writer, Jessica enjoys writing about all subjects but specifically loves covering beauty and health-related subjects. In her free time, Jessica spends her time creating art, playing with her adorable dog, and traveling to new places.
How long does it take for TUDCA to lower liver enzymes?
The effect of TUDCA on liver serum enzymes was evident after 1 month and reached a maximum effect after 3 months, when TUDCA had significantly lowered AST (−44%), ALT (−49%), and GGT (−38%) (P
Can I drink alcohol after 3 hours of taking medicine?
Timing is important – Alcohol and medicines can interact harmfully even if they are not taken at the same time. Mixing alcohol and medicines puts you at risk for dangerous reactions. Protect yourself by avoiding alcohol if you are taking a medication and don’t know its effect.
Symptom/Disorders | Medication (Brand name) | Medication (Generic name) | Some possible reactions with alcohol |
---|---|---|---|
Allergies/Colds/Flu |
Alavert® |
Loratadine | Drowsiness, dizziness; increased risk for overdose |
Atarax® |
Hydroxyzine | ||
Benadryl® |
Diphenhydramine | ||
Clarinex® |
Desloratadine | ||
Claritin®, Claritin-D® |
Loratadine | ||
Dimetapp® Cold &Allergy |
Brompheniramine | ||
Sudafed® Sinus & Allergy |
Chlorpheniramine | ||
Triaminic® Cold & Allergy |
Chlorpheniramine | ||
Tylenol® Allergy Sinus |
Chlorpheniramine | ||
Tylenol® Cold & Flu |
Chlorpheniramine | ||
Zyrtec® |
Cetirizine | ||
Angina (chest pain), coronary heart disease |
Isordil® |
Isosorbide Nitroglycerin | Rapid heartbeat, sudden changes in blood pressure, dizziness, fainting |
Anxiety and epilepsy |
Ativan® |
Lorazepam | Drowsiness, dizziness; increased risk for overdose; slowed or difficulty breathing; impaired motor control; unusual behavior; memory problems |
BuSpar® |
Buspirone | ||
Klonopin® |
Clonazepam | ||
Librium® |
Chlordiazepoxide | ||
Paxil® |
Paroxetine | ||
Valium® |
Diazepam | ||
Xanax® |
Alprazolam | ||
Herbal preparations (Kava Kava) |
Liver damage, drowsiness | ||
Arthritis |
Celebrex® |
Celecoxib | Ulcers, stomach bleeding, liver damage |
Naprosyn® |
Naproxen | ||
Voltaren® |
Diclofenac | ||
Attention and concentration (Attention deficit/hyperactivity disorder) |
Adderall® |
Amphetamine/dextro-amphetamine | Dizziness, drowsiness, impaired concentration (methylphenidate, dexmethylphenidate); possible increased risk for heart problems (amphetamine, dextroamphetamine, lisdexamfetamine); liver damage (atomoxetine) |
Concerta®, Ritalin® |
Methylphenidate | ||
Dexedrine® |
Dextroamphetamine | ||
Focalin® |
Dexmethylphenidate | ||
Strattera® |
Atomoxetine | ||
Vyvanse® |
Lisdexamfetamine | ||
Blood clots |
Coumadin® |
Warfarin | Occasional drinking may lead to internal bleeding; heavier drinking also may cause bleeding or may have the opposite effect, resulting in possible blood clots, strokes, or heart attacks |
Cough |
Delsym®, Robitussin Cough® |
Dextromethorpan | Drowsiness, dizziness; increased risk for overdose |
Robitussin A–C® |
Guaifenesin + codeine | ||
Depression |
Abilify® |
Aripriprazone | Drowsiness, dizziness; increased risk for overdose; increased feelings of depression or hopelessness (all medications); impaired motor control (quetiapine, mirtazapine); increased alcohol effect (bupropion); liver damage (duloxetine) Monoamine oxidase inhibitors (MAOIs), such as tranylcypromine and phenelzine, when combined with alcohol, may result in serious heart-related side effects. Risk for dangerously high blood pressure is increased when MAOIs are mixed with tyramine, a byproduct found in beer and red wine |
Anafranil® |
Clomipramine | ||
Celexa® |
Citalopram | ||
Clozaril® |
Clozapine | ||
Cymbalta® |
Duloxetine | ||
Desyrel® |
Trazodone | ||
Effexor® |
Venlafaxine | ||
Elavil® |
Amitriptyline | ||
Geodon® |
Ziprasidone | ||
Invega® |
Paliperidone | ||
Lexapro® |
Escitalopram | ||
Luvox® |
Fluvoxamine | ||
Nardil® |
Phenelzine | ||
Norpramin® |
Desipramine | ||
Pamate® |
Tranylcypromine | ||
Paxil® |
Paroxetine | ||
Pristiq® |
Desevenlafaxine | ||
Prozac® |
Fluoxetine | ||
Remeron® |
Mirtazapine | ||
Risperdal® |
Risperidone | ||
Seroquel® |
Quetiapine | ||
Serzone® |
Nefazodone | ||
Symbyax® |
Fluoxetine/Olanzapine | ||
Wellbutrin® |
Bupropion | ||
Zoloft® |
Sertraline | ||
Zyprexa® |
Olanzapine | ||
Herbal preparations (St. John’s Wort) |
|||
Diabetes |
Diabinese® |
Chlorpropamide | Abnormally low blood sugar levels, flushing reaction (nausea, vomiting, headache, rapid heartbeat, sudden changes in blood pressure); symptoms of nausea and weakness may occur (metformin) |
Glucotrol® |
Glipizide | ||
Glucophage® |
Metformin | ||
Glynase®, DiaBeta®, Micronase® |
Glyburide | ||
Orinase® |
Tolbutamide | ||
Tolinase® |
Tolazamide | ||
Enlarged prostate |
Cardura® |
Doxazosin | Dizziness, light headedness, fainting |
Flomax® |
Tamsulosin | ||
Hytrin® |
Terazosin | ||
Minipress® |
Prazosin | ||
Heartburn, indigestion, sour stomach |
Axid® |
Nizatidine | Rapid heartbeat; increased alcohol effect; sudden changes in blood pressure (metoclopramide) |
Reglan® |
Metoclopramide | ||
Tagamet® |
Cimetidine | ||
Zantac® |
Ranitidine | ||
High blood pressure |
Accupril® |
Quinapril | Dizziness, fainting, drowsiness; heart problems such as changes in the heart’s regular heartbeat (arrhythmia) |
Calan® |
Verapamil | ||
Capozide® |
Hydrochlorothiazide | ||
Cardura® |
Doxazosin | ||
Catapres® |
Clonidine | ||
Cozaar® |
Losartan | ||
Hytrin® |
Terazosin | ||
Lopressor® HCT |
Hydrochlorothiazide | ||
Lotensin® |
Benzapril | ||
Minipress® |
Prazosin | ||
Norvasc® |
Amlodipine mesylate | ||
Prinivil®, Zestril® |
Lisinopril | ||
Vaseretic® |
Enalapril | ||
High cholesterol |
Advicor® |
Lovastatin + Niacin | Liver damage (all medications); increased flushing and itching (niacin), increased stomach bleeding (pravastatin + aspirin) |
Altocor® |
Lovastatin | ||
Crestor® |
Rosuvastatin | ||
Lipitor® |
Atorvastatin | ||
Mevacor® |
Lovastatin | ||
Niaspan® |
Niacin | ||
Pravachol® |
Pravastatin | ||
Pravigard™ |
Pravastatin + Aspirin | ||
Vytorin™ |
Ezetimibe + Simvastatin | ||
Zocor® |
Simvastatin | ||
Infections |
Acrodantin® |
Nitrofurantoin | Fast heartbeat, sudden changes in blood pressure; stomach pain, upset stomach, vomiting, headache, or flushing or redness of the face; liver damage (isoniazid, ketoconazole) |
Flagyl® |
Metronidazole | ||
Grisactin® |
Griseofulvin | ||
Nizoral® |
Ketoconazole | ||
Nydrazid® |
Isoniazid | ||
Seromycin® |
Cycloserine | ||
Tindamax® |
Tinidazole | ||
Zithromax® |
Azithromycin | ||
Mood stabilizers |
Depakene®, Depakote® |
Valproic acid | Drowsiness, dizziness; tremors; increased risk for side effects, such as restlessness, impaired motor control; loss of appetite; stomach upset; irregular bowel movement; joint or muscle pain; depression; liver damage (valproic acid) |
Eskalith®, Eskalith®CR, Lithobid |
Lithium | ||
Muscle pain |
Flexeril® |
Cyclobenzaprine | Drowsiness, dizziness; increased risk of seizures; increased risk for overdose; slowed or difficulty breathing; impaired motor control; unusual behavior; memory problems |
Soma® |
Carisoprodol | ||
Nausea, motion sickness |
Antivert® |
Meclizine | Drowsiness, dizziness; increased risk for overdose |
Dramamine® |
Dimenhydrinate | ||
Phenergan® |
Promethazine | ||
Pain (such as muscle ache, minor arthritis pain), fever, inflammation |
Advil® |
Ibuprofen | Stomach upset, bleeding and ulcers; liver damage (acetaminophen); rapid heartbeat |
Aleve® |
Naproxen | ||
Excedrin® |
Aspirin, Acetaminophen | ||
Motrin® |
Ibuprofen | ||
Tylenol® |
Acetaminophen | ||
Seizures |
Dilantin® |
Phenytoin | Drowsiness, dizziness; increased risk of seizures (levetiracetam, phenytoin); unusual behavior and changes in mental health (such as thoughts of suicide) (topiramate) |
Horizant®, Neurontin® |
Gabapentin | ||
Keppra® |
Levetiracetam | ||
Klonopin® |
Clonazepam | ||
Phenobarbital | |||
Lamictal® |
Lamotrigine | ||
Lyrica® |
Pregabalin | ||
Tegretol® |
Carbamazepine | ||
Topamax® |
Topiramate | ||
Trileptal® |
Oxcarbazepine | ||
Barbiturates | |||
Severe pain from injury, postsurgical care, oral surgery, migraines |
Darvocet–N® |
Propoxyphene | Drowsiness, dizziness; increased risk for overdose; slowed or difficulty breathing; impaired motor control; unusual behavior; memory problems |
Demerol® |
Merepidine | ||
Fiorinal® with codeine |
Butalbital + codeine | ||
Percocet® |
Oxycodone | ||
Vicodin® |
Hydrocodone | ||
Sleep problems |
Ambien® |
Zolpidem | Drowsiness, sleepiness, dizziness; slowed or difficulty breathing; impaired motor control; unusual behavior; memory problems |
Lunesta™ |
Eszopiclone | ||
Prosom™ |
Estazolam | ||
Restoril® |
Temazepam | ||
Sominex® |
Diphenhydramine | ||
Unisom® |
Doxylamine | ||
Herbal preparations (chamomile, valerian, lavender) |
Increased drowsiness |
Can I drink while taking TUDCA?
Side Effects – TUDCA is very well tolerated and most users experience no side effects from supplementing at the recommended 500 mg dose. Diarrhea has occasionally been reported in some users taking over 1000 mg of TUDCA per day. TUDCA should not be taken before drinking alcohol as the combination of alcohol and TUDCA may be more damaging to the liver than alcohol alone.
Does TUDCA detox the liver?
What do you know about your liver? Did you know that it’s one of your body’s largest and most important organs? The liver acts as a filter which catches toxins and waste and cleanses them from your system. Alcohol, fat, sugar, these are just a few of the things that the liver filters out.
What to expect after taking TUDCA?
Some people may experience side effects from taking TUDCA, such as diarrhea or constipation – As helpful as TUDCA can be in treating liver diseases, like any other supplement it’s important to be aware of possible side effects. Some people may experience changes in their digestion when taking TUDCA, either in the form of unpleasant diarrhea or difficult constipation.
- Although these reactions rarely cause any major damage, they can be quite uncomfortable.
- It’s advisable to speak with your physician before taking new supplements so that you get the most suitable advice, and for them to keep a lookout for potential changes.
- Fortunately, if side effects occur at all, it is usually very mild.
The potential benefits of supplementing with TUDCA far outweigh any potential risks.
Can TUDCA reverse liver damage?
New treatments? – Raúl Méndez, ICREA researcher at IRB Barcelona and co-leader of the study, explains that “knowledge of the hepatic function of CPEB4 could be useful as a predictive marker for those people with variants of this protein, thus serving to prevent this condition, for example, through improvements in diet and better choice of eating times.
- Such knowledge could also contribute to the development of treatments that boost the clean-up process”.
- The researchers have managed to r everse fatty liver disease in mice by treatment with a drug called Tudca, which is currently used for other disorders.
- This drug exerts the same function as the proteins that are activated by CPEB4 and that are responsible for cleaning up the cell, namely chaperones.
“In the future it may be possible to design molecules like Tudca that specifically target CPEB4, thus enhancing the liver clean-up process,” proposes Méndez. ” This basic research study does not have a direct and immediate clinical application, but it lays down the foundation for the applied science that follows,” says Mercedes Fernández, co-leader of the study and head of the group at IDIBAPS and the Biomedical Research Networking Center of Hepatic and Digestive Diseases (CIBEREHD).
Fernández warns, “Given the obesity epidemic in the US and worldwide, an increase in those affected by non-alcoholic fatty liver disease is expected in the coming decades and we still do not have a suitable treatment for this condition; A fundamental understanding of this medical problem is therefore essential for development of novel treatment strategies.” It is estimated that between 80 and 100 million people in the US alone suffer from fatty liver disease,
People with this disease have an increased risk of cirrhosis and liver cancer. Moreover, liver cancer incidence has more than tripled since 1980 and is the primary cause of death in patients with cirrhosis. This study has received funding from the Worldwide Cancer Research Foundation in the UK, the Spanish Association Against Cancer (AECC), the Fundación Botín by Banco Santander through its Santander Universities Global Division, the Spanish Ministry of Economy and Competitiveness/ERDF and the Government of Catalonia.
What does TUDCA do to the brain?
Journal List Neural Regen Res v.12(1); 2017 Jan PMC5319238
As a library, NLM provides access to scientific literature. Inclusion in an NLM database does not imply endorsement of, or agreement with, the contents by NLM or the National Institutes of Health. Learn more about our disclaimer. Neural Regen Res.2017 Jan; 12(1): 62–63.
Neurological diseases and the neuroinflammatory response : Neurological diseases are usually accompanied by dramatic changes in the tissue homeostasis, inducing a neuroinflammatory environment that leads to the progressive activation of central nervous system (CNS) resident cells, and in certain cases, to the infiltration of leukocytes into the CNS.
If this neuroinflammatory response persists, it is toxic for CNS resident cells, especially for neurons, and consequently is detrimental for the progression and outcome of neurological diseases. The blood-brain barrier (BBB) is a physical and functional barrier that facilitates the maintenance of homeostasis restricting the traffic of substances and cells from the blood to the CNS parenchyma.
- CNS resident cells (mainly glial cells) actively monitor and detect any alteration in tissue homeostasis.
- Any unbalance (such as infections, trauma, stroke, and neurodegeneration) leads to the activation of CNS glial cells (mainly astrocytes and microglia), to counterbalance the alteration and bring back homeostasis (Tian et al., 2012).
Upon activation, microglial cells and astrocytes undergo severe morphological and structural changes, ranging from a resting to a reactive state. Reactive glial cells show enhanced release of pro- and anti-inflammatory mediators, phagocytic capacity and increased migration to the insult site.
- If this glial response cannot restore proper physiological condition, the inflammatory status is maintained by the secretion of pro-inflammatory mediators, resulting in chronic neuroinflammation and the loss of white and gray matter distinctive of CNS pathologies (Popovich et al., 2002).
- Moreover, pro-inflammatory cytokines and chemokines alter the BBB permeability, allowing the activation and recruitment of leukocytes to the CNS parenchyma (Weiss et al., 2009; Tian et al., 2012) that help to maintain the chronic neuroinflammation as a feed-back mechanism with detrimental effects on the progression and outcome of neurological diseases.
Tauroursodeoxycholic acid (TUDCA) is a neuroprotective bile conjugate : TUDCA is a conjugated derivative of the ursodeoxycholic bile acid, with neuroprotective effects in several animal models of neurodegenerative diseases, such as Alzheimer’s disease (Nunes et al., 2012), Huntington’s disease (Keene et al., 2002), Parkinson’s disease (Castro-Caldas et al., 2012) and stroke (Rodrigues et al., 2002).
- Bile acids are very interesting therapeutic tools because they cross the BBB, and they are used for the chronic treatment of primary biliary cirrhosis, with no side effect attached (Lindor et al., 1994).
- Indeed, TUDCA treatment has a beneficial effect on amyotrophic lateral sclerosis patients (Elia et al., 2016).
TUDCA inhibits nuclear factor-kappa B (NF-κB) activation in glial cells under pro-inflammatory conditions : In addition to the direct neuroprotective effect, TUDCA exerts a direct anti-inflammatory effect on both astrocytes and microglial cells in vitro and in a mouse model of acute neuroinflammation (Yanguas-Casás et al., 2014).
- Under pro-inflammatory conditions, TUDCA reduces NF-κB activation both in astrocytes and microglia, leading to a decrease in the nitrite release by these cells, through a transcriptional and translational diminution of the inducible enzyme nitric oxide synthase (iNOS).
- Mice treated with both the bacterial lipopolysaccharide (LPS, a single intracerebroventricular injection of 2 mg/kg) and TUDCA (a daily intraperitoneal injection of 500 mg/kg for three days) reduced microglia activation to control levels 3 days after LPS injection (Yanguas-Casás et al., 2014).
Apart from restricting the activation of these cells, the decrease in nitrite secretion limits the spreading and the chronification of the pro-inflammatory response to surrounding cells. Besides, TUDCA treatment reduces the migratory capacity of microglial cells, preventing an exacerbated pro-inflammatory response in the insult site (Yanguas-Casás et al., 2014).
- The treatment with TUDCA reduces endothelium activation and decreases the expression of vascular adhesion proteins ( e.g,, VCAM-1).
- Moreover, TUDCA also reduces the monocyte chemoattractant protein 1 (MCP-1) expression in microglia and astrocytes under pro-inflammatory conditions (Yanguas-Casás et al., 2014).
These proteins are required for both microglial migration and leukocyte transmigration into the CNS parenchyma (Weiss et al., 2009). These results suggest that TUDCA might reduce leukocyte extravasation to the inflammation site in the CNS. Additional anti-inflammatory effect of TUDCA inducing TGF-β pathway : Recently, we found that TUDCA has an additional anti-inflammatory effect in neuroinflammation through the regulation of the transforming growth factor β (TGF-β) pathway (Yanguas-Casás et al., 2016; Figure 1 ).
TGF-β is a pleiotropic cytokine involved in a wide variety of physiological and pathological conditions that actively modulate the inflammatory process by a direct effect on immune and CNS resident cells under physiological and neuropathological conditions (Blobe et al., 2000). TGF-β inhibits the activation of pro-inflammatory pathways, reducing the production and release of pro-inflammatory mediators.
Besides, TGF-β drives microglial cells towards an anti-inflammatory phenotype, contributing to homeostasis restoration. In a mouse model of acute neuroinflammation by intracerebraventricular injection of LPS, TUDCA increases the transcription of TGF-β2 and TGF-β3 in the hippocampus of LPS treated mice, compared to those treated with LPS alone.
- We found that TGF-β3 protein expression was increased in the brains of those mice.
- Interestingly, TGF-β3 expression was limited to certain cell types, such as microglia, endothelial cells and some neurons, but was absent in astrocytes (Yanguas-Casás et al., 2016).
- The inhibition of TGF-β receptor (ALK5) in mice treated with TUDCA reduced TGF-β3 expression and restored microglia activation to the same levels as mice treated with LPS alone.
This result suggests that TUDCA-induced TGF-β3 expression might be regulated by TGF-β pathway as a positive feed-back. Moreover, TGF-β pathway activation is required for TUDCA-induced inhibition of microglia activation in mice treated with LPS (Yanguas-Casás et al., 2016). Proposed model for the effect of tauroursodeoxycholic acid (TUDCA) in the neuroinflammatory process. (A) Under homeostatic conditions, the blood-brain barrier (BBB) restricts the entry of circulating blood cells into the central nervous system (CNS) parenchyma.
The low permeability to circulating blood substances and leukocytes and the basal concentration of anti-inflammatory mediators (such as transforming growth factor β (TGFβ)) in the CNS allow a resting-homeostatic state in CNS resident cells. (B) CNS neuroinflammation drives the activation of resident glial cells (such as microglia and astrocytes) and the secretion of inflammatory mediators ( e.g,, monocyte chemoattractant protein 1 (MCP-1)) that promote the infiltration of peripheral leukocytes into the injured parenchyma.
Endothelial cells increase the expression of surface adhesion molecules ( e.g,, vascular cell adhesion molecule 1 (VCAM-1)). Both, reactive astrocytes and activated endothelium, increase the permeability of the BBB. Circulating leukocytes adhere to the activated endothelium and infiltrate into the CNS, perpetuating the inflammatory response by a direct interaction with neurons and glial cells.
- During early inflammation, the activation of matrix metalloproteases releases TGFβ from the extracellular matrix, increasing the activation of the TGFβ pathway and counterbalancing the pro-inflammatory response.
- C) Under inflammatory conditions, TUDCA treatment increases the activation of the TGFβ pathway and the expression of TGFβ3 in neurons, microglia and endothelial cells.
The activation of TGFβ pathway drives the deactivation of glial cells and the endothelium, leading to an anti-inflammatory microenvironment with reduced expression of vascular adhesion molecules ( e.g,, VCAM-1) and inflammatory mediators ( e.g,, MCP-1), and therefore to a reduced BBB permeability and leukocyte infiltration.
- Conclusions : Although the neuroprotective effects of TUDCA have been widely described, little is known about the effect of TUDCA on glial cells.
- In addition to its direct neuroprotective effect on different animal models of neurological diseases, TUDCA might have an indirect neuroprotective effect through the inhibition of glia and endothelium activation under pro-inflammatory conditions.
TUDCA treatment inhibits NF-κB pathway and increases further TGF-β pathway favoring the resolution of the inflammatory process. The anti-inflammatory environment promoted by glial cells might lead to an increase of neuronal survival and a faster restoration of neural function in the CNS.
Does TUDCA cause detox?
The Role of the Liver in Detoxification The liver plays an essential role in protecting you. Every day, your body is exposed to harmful chemicals. Your liver, kidneys, large intestine, lymphatic system, and sweat glands work together to reduce the buildup of these chemicals.
There are three phases of detoxification: Phase I: The first phase of detoxification occurs mainly in the liver and helps to transform dangerous, fat-soluble molecules into less harmful intermediates products that will be easier to excrete.Phase II: The conjugation process – the addition of a chemical group – to a by-product of phase I, making it water-soluble and, therefore, less harmful.Phase III: The now water-soluble molecules are now moved out of your liver cells and then excreted through the kidneys and intestines through urine and bile.Each phase is essential, and they all work together to assist the body in eliminating harmful elements.Signs of poor detoxification functionSigns of poor detoxification are broad, including but not limited to: difficulty digesting fats, bad breath, acne, premenstrual cramping, hypoglycemia, environmental allergies, skin rashes, difficulty losing weight. Supporting your liver
Your liver handles a lot of toxins. You need to detox these harmful compounds. And you need to keep them moving out of your liver and the rest of your body regularly to minimize their harmful effects. If toxins pile up, it could lead to liver damage, as well as disease in other parts of your body.
For example, toxins may contribute to obesity, cancer, and dementia. And they could be a factor in complex chronic illnesses such as fibromyalgia. You can do several things to help your liver with the three phases of detoxification. TUDCA: This consists of water-soluble bile acids and is also known as tauroursodeoxycholic acid.
Studies suggest TUDCA promotes bile secretion, which is essential to get rid of toxins. And when TUDCA is combined with NAC, carbon-based binders, and melatonin, it also helps support Phase 1 and Phase 2 detox. Fiber: Some types of fiber you consume in foods may also help bind bile in your gut; fiber is another way to encourage toxin excretion in your stools.
Intestinal-moving herbs: Herbs such as aloe vera and ginger gently stimulate your gut to help prevent constipation. Ideally, you should move your bowels two or three times a day during your detox journey. That supports toxin elimination. Good hydration: You need to consume enough water to support eliminating toxins through your urine and stools.
Good hydration helps your kidneys work better. Being well-hydrated also helps reduce your risk of constipation. If your liver detox is lagging or your drainage is backed up, you may feel unwell. Plus, you’ll be at an increased risk of chronic illness. So, support liver detox with good nutrition and antioxidant-rich herbs.
Best foods for the liver Fatty fish such as salmon, sardines, and herring are good omega-3 fatty acids. Omega-3s also have anti-inflammatory and anti-cancer properties and might help reduce fatty liver disease. Be sure to choose fish that is low in mercury to avoid further liver damage. If you don’t like fish, taking fish oil for fatty liver offers some of the same benefits.
Beets are rich in antioxidants, have anti-cancer properties, and help reduce liver enzymes and inflammation. Beet stalks and leaves also have similar health benefits. Cruciferous Vegetables like broccoli, cauliflower, kale, chard, mustard, collard greens, bok choy, watercress, horseradish, cabbage, and Brussels sprouts support the liver’s ability to detoxify.
Is too much TUDCA bad?
TUDCA Side Effects – TUDCA supplements are generally considered safe when taken within the recommended amounts. When exceeding 1500 mg daily, some people have reported experiencing diarrhea. Aside from that one complication, there are no other reported side effects for TUDCA.
Is 250mg TUDCA enough?
Recommended Dosage – Our recommended dosage for TUDCA when supplementing to support liver and eye health is to take two 250 mg capsules per day. We do not recommend taking more than six capsules (1500 mg) per day. As TUDCA is water soluble it does not need to be taken with food.
How many days does it take to rejuvenate your liver?
Can liver damage be reversed? – The liver is a unique organ. It is the only organ in the body that is able to regenerate. With most organs, such as the heart, the damaged tissue is replaced with scar, like on the skin. The liver, however, is able to replace damaged tissue with new cells.
If up to 50 to 60 percent of the liver cells may be killed within three to four days in an extreme case like a Tylenol overdose, the liver will repair completely after 30 days if no complications arise. Complications of liver disease occur when regeneration is either incomplete or prevented by progressive development of scar tissue within the liver.
This occurs when the damaging agent such as a virus, a drug, alcohol, etc., continues to attack the liver and prevents complete regeneration. Once scar tissue has developed it is very difficult to reverse that process. Severe scarring of the liver is the condition known as cirrhosis.
Does TUDCA reduce inflammation?
Abstract – The bile acid tauroursodeoxycholic acid (TUDCA) reduces cell death under oxidative stress and inflammation. Implants of bone marrow-derived stromal cells (bmSC) are currently under investigation in clinical trials of spinal cord injury (SCI).
- Since cell death of injected bmSC limits the efficacy of this treatment, the cytoprotective effect of TUDCA may enhance its benefit.
- We therefore studied the therapeutic effect of TUDCA and its use as a combinatorial treatment with human bmSC in a rat model of SCI.
- A spinal cord contusion injury was induced at thoracic level T9.
Treatment consisted of i.p. injections of TUDCA alone or in combination with one injection of human bmSC into the cisterna magna. The recovery of motor functions was assessed during a surveillance period of six weeks. Biochemical and histological analysis of spinal cord tissue confirmed the anti-inflammatory activity of TUDCA.
- Treatment improved the recovery of autonomic bladder control and had a positive effect on motor functions in the subacute phase, however, benefits were only transient, such that no significant differences between vehicle and TUDCA-treated animals were observed 1–6 weeks after the lesion.
- Combinatorial treatment with TUDCA and bmSC failed to have an additional effect compared to treatment with bmSC only.
Our data do not support the use of TUDCA as a treatment of SCI. Keywords: bile acid, spinal cord injury, bone marrow-derived stromal cells, rat, neuroinflammation
Can I take TUDCA and milk thistle together?
Tendencias en las opiniones Compra verificada This is the BEST OTC Liver support/protectant! Read my product review for a complete breakdown!,support/protectant. Many people are familiar with & most likely have taken Milk Thistle or maybe even Liv52,which are fine, but to be real honest, TUDCA is is FAR BETTER! • Keep reading to find out why! What’s up my Amazon Health & Fitness Family, it’s your boy HardbodybyAnthony.
Anyway, for those of you who have not read or seen any of my reviews, I am Certified Master Trainer with over 20 years under my belt & I have many certifications, one of which is a certification in Supplementation & Basic Nutrition, so because of my years of knowledge and dedication in helping people achieve healthier lives through exercise & nutrition, is the reason why I do these reviews.
in hopes I can help someone (even if just one person) with a bit of knowledge. *** I first want to say that I am NOT affiliated with, endorsed by or sponsored by ANY SUPPLEMENT COMPANY WHATSOEVER! I do NOT profit by my reviews or receive any monetary gains.
Simply trying to help people make the best choice in this extremely shady business! *** • This review is on: Nutricost Tudca 250mg, 60 Capsules (Tauroursodeoxycholic Acid) – Premium Quality • So anyone that takes a lot of supplements as I do, or oral medications of any kind, drinks or party’s & definitely for cycle support should be taking a liver support/protectant.
Many people are familiar with & most likely have taken Milk Thistle or maybe even Liv52,which are fine, but to be real honest, TUDCA is is FAR BETTER! • Keep reading to find out why!• TUDCA which is Tauroursodeoxycholic acid, is a chemical naturally produced in the human body & it is in a form of salt before it transforms into TUDCA.
It is said to have a few benefits & the following are to name a few:1) Said to protect nerve cells and it also protects the liver.2) Helps to control cholesterol levels in the liver because it breaks down fats resulting in a healthy liver.3) Said to have the ability to burn fats.Now on to the the main reasons this is top shelf: • It decrease liver enzymes that cause cholestasis & for those that have no clue what that is, cholestasis interrupts the flow of bile through the liver and by decreasing these enzymes, Tauroursodeoxycholic Acid can promote healthy cholesterol levels.
TUDCA also promotes liver cell regeneration & to be honest, I recommend to combine this with Milk Thistle (NOT if you are using any methylated Prohormone or oral steroid), because it is a much more effective way to promote liver health and protection.
Tauroursodeoxycholic Acid is also good for improving insulin sensitivity in muscle tissue and the liver. Lastly, it will increase the bile acids in our bodies which will help the body utilize fat for energy, and promote a healthy metabolism. • HUGE FACT: There is another product called UDCA which is prescription ONLY.
Why am I mentioning this as a comparison? Well when TUDCA reaches the intestines, it will be transformed to UDCA. UDCA will then be combined with taurine (Liver produces Taurine) & this mixture will lead to the production of TUDCA. • These are normal size capsules, so they are easy to ingest, & are well within the expiration date.
The recommended dosage is 200-300mg/day depending on your weight, liver health, drinking habits, oral medication usage & these are right on point with their dosage. Their price $29.95 for a 2 month supply is right where others of it’s kind is, so bravo to Nutricost with this product. I have purchased this a couple times and will continue.
I highly recommend. : Tendencias en las opiniones
Can TUDCA cause depression?
Tauroursodeoxycholic acid produces antidepressant-like effects in a chronic unpredictable stress model of depression via attenuation of neuroinflammation, oxido-nitrosative stress, and endoplasmic reticulum stress.
Can you take supplements before drinking alcohol?
From the earliest days of alcohol consumption in Ancient Egypt to modern-day Aperol spritz and craft beer crazes, humans have been dealing with the same problem — hangovers. Alcohol may relax you and make you feel great in the moment, but if you drink too much, you inevitably wake up the next morning (or afternoon) feeling awful.
- And unfortunately, the older you get, the worse alcohol tends to make you feel.
- This is why OnMi came up with a better solution in the form of an expertly crafted combination of vitamins: a Hangover Relief Patch,
- Just apply one an hour before you start drinking, then apply a fresh one the next morning.
Easy. But does it actually work? Can you take vitamins with alcohol ? Or is v itamins and alcohol interaction dangerous? OnMi dove into the scientific research out there to find the truth. Vitamins and Alcohol Interaction : An Answer Long story short, the answer to the question of ” can you take vitamins with alcohol ” is: yes, and it can even be beneficial to do so.
Many people think this is because drinking alcohol negatively affects our body’s ability to absorb vitamins, but this meta-study found that the consumption of alcohol has no effect on our ability to absorb vitamins properly. The scientists concluded that the only culprits of a hangover are “alcohol and its metabolites”, meaning alcohol and the enzymes that break it down.
If hangovers are really just caused by alcohol and how it is metabolized, what, then, could one do to speed up the breakdown of alcohol to get it out in time to wake up with a smile on one’s face and a song in one’s heart? B vitamins are the star of the show here.
B vitamins are essential enzymes that get their rave on during the process of turning carbohydrates, such as alcohol, into energy. Thus, taking more B vitamins can assist your body in efficiently metabolizing alcohol to afford you the utmost of comfort the morning after a big night out. B vitamins and alcohol interaction is a completely safe combination that could improve your hangover.
Why an OnMi Patch is the Best for Vitamins and Alcohol Interaction So why not just buy B vitamins? Because OnMi has a better product for your Sunday Scaries. Turns out, your body may only be able to use 30% of the vitamins you buy in powder or capsule form.
Everything else gets flushed down the toilet along with all the money you spent buying those vitamins. Traditional vitamins have yet another downside: you have to swallow them. When your stomach’s already feeling queasy, forcing yourself to swallow a couple of pills along with your morning coffee can make you feel even more nauseated.
Even if you manage to keep things together, the nausea itself is far from pleasant. OnMi’s hangover patch solves both of those problems. It contains vitamins B1, B3, and B6, which your body desperately needs after a night on the town. Plus, we included guarana for a natural energy boost.
Because it’s a patch, there’s no pill-swallowing or additional nausea with which you have to deal. Perhaps most importantly, your body is still able to absorb up to 90% of the vitamins in the patch, making one patch far more effective than capsules and powders. Turns out the answer to the question of “can you take vitamins with alcohol ” was even better than you thought.
Can You Take Vitamins with Alcohol ? Yes, but You Need Water too. Even though the answer to ” can you take vitamins with alcohol ” is an emphatic “yes”, our patches can’t fix everything. If you apply one before you go out and a second one in the morning, you should feel better than you would otherwise, but there’s another aspect of hangovers that our patch can’t address — dehydration.
- Most people know this part, but since alcohol acts as a diuretic, drinking causes you to go to the bathroom a lot, and while alcoholic beverages are mostly water, they are not enough to replace the water you lose.
- Drink too much, and you’ll end up dehydrated.
- And if you’re already dehydrated when you start drinking, even a moderate amount of alcohol can leave you with a dry throat and a headache.
It may be possible to mask the feeling temporarily, but when your body’s short on water, the only thing that will actually help you feel better is more water. You must rehydrate. And since we still have yet to figure out a way to magically create dehydrated water, your only option is good, old-fashioned H2O.
What does TUDCA interact with?
Summary Tauroursodeoxycholic acid is the taurine conjugate of ursodeoxycholic acid with antiapoptotic and ER stress response dampening effects used in some countries to treat gallstones. It is also being investigated for a wide variety of other conditions.
Brand Names Relyvrio Generic Name Tauroursodeoxycholic acid DrugBank Accession Number DB08834 Background Tauroursodeoxycholic acid, also known as ursodoxicoltaurine, is a highly hydrophilic tertiary bile acid 3 that is produced in humans at a low concentration.3 It is a taurine conjugate of ursodeoxycholic acid 2 with comparable therapeutic efficacy and safety, 3 but a much higher hydrophilicity.1 Normally, hydrophilic bile acids regulates hydrophobic bile acids and their cytotoxic effects.
Tauroursodeoxycholic acid can reduce the absorption of cholesterol in the small intestine, thereby reducing the body’s intake of dietary cholesterol and the body cholesterol content.4 Tauroursodeoxycholic acid is currently used in Europe to treat and prevent gallstones as a bile acid derivative.7 Due to a range of its molecular properties – namely its anti-apoptotic effects – tauroursodeoxycholic acid has been examined in inflammatory metabolic diseases and neurodegenerative diseases.2, 3 Type Small Molecule Groups Approved, Investigational Structure Weight Average: 499.71 Monoisotopic: 499.296759347 Chemical Formula C 26 H 45 NO 6 S Synonyms
- Tauroursodeoxycholate
- Tauroursodesoxycholic acid
- Taurursodiol
- TUDCA
- Ursodeoxycholyltaurine
- Ursodoxicoltaurine
External IDs
UR-906
Indication Tauroursodeoxycholic acid is used to prevent and treat gallstone formation.7 Tauroursodeoxycholic acid is used in combination with phenylbutyric acid to treat amyotrophic lateral sclerosis (ALS) in adults.8, 9 Reduce drug development failure rates Build, train, & validate machine-learning models with evidence-based and structured datasets. Build, train, & validate predictive machine-learning models with structured datasets. Associated Conditions
- Amyotrophic Lateral Sclerosis (ALS)
- Gallstones
Contraindications & Blackbox Warnings Avoid life-threatening adverse drug events Improve clinical decision support with information on contraindications & blackbox warnings, population restrictions, harmful risks, & more. Avoid life-threatening adverse drug events & improve clinical decision support.
Pharmacodynamics Tauroursodeoxycholic acid works to decrease bile acid 1 and cholesterol levels.4 It reduces the cholesterol content and increases the bile acid content in gallbladder bile to prevent the formation of cholesterol gallstones.4 Tauroursodeoxycholic acid possesses anti-apoptotic and anti-inflammatory properties.
These findings provoked the investigations of tauroursodeoxycholic acid as a potential therapeutic agent for neurodegenerative diseases, such as amyotrophic lateral sclerosis, Alzheimer’s disease, and Parkinson’s disease.2 Other studies also suggest that tauroursodeoxycholic acid can promote angiogenesis and suppress adipogenesis of adipose-derived mesenchymal stem cells (MSCs).
Anti-osteoporotic effects of tauroursodeoxycholic acid have also been documented, as it was shown to enhance osteogenic differentiation of bone marrow-derived MSCs.3 Mechanism of action About 90% of gallstones are formed by cholesterol, which may be caused by altered gut microbiota from a high-fat diet and other factors.
The gut microbiota regulates bile acid metabolism; thus, altered composition in gut microbiota may significantly change the bile acid pool and alter cholesterol secretion.4 While the exact mechanism of action of tauroursodeoxycholic acid in reducing and preventing gallstone formation is unclear, tauroursodeoxycholic acid may achieve this effect in a number of ways.
- A recent mouse study suggests that tauroursodeoxycholic acid inhibits intestinal cholesterol absorption and lowers liver cholesterol levels by upregulating the bile acid excretion from the liver to the gallbladder.
- Tauroursodeoxycholic acid lowers the bile cholesterol saturation in the gallbladder, thereby increasing the solubility of cholesterol in bile.
It can also maintain a specific gut microbiota composition to promote the synthesis of bile acids and reduce liver inflammation caused by the lipopolysaccharide in the blood. Ultimately, tauroursodeoxycholic acid enhances the synthesis of bile acids in the liver and reduces cholesterol in the serum and liver.4 Tauroursodeoxycholic acid inhibits cell apoptosis by disrupting the mitochondrial pathway of cell death.
It works by inhibiting oxygen-radical production, ameliorating endoplasmic reticulum (ER) stress, and stabilizing the unfolded protein response. Other anti-apoptotic processes mediated by tauroursodeoxycholic acid include cytochrome c release, caspase activation, DNA and nuclear fragmentation, and inhibition of p53 transactivation.
It is believed that tauroursodeoxycholic acid works on multiple cellular targets to inhibit apoptosis and upregulate survival pathways.2
Target | Actions | Organism |
---|---|---|
U Integrin alpha-5 | activator | Humans |
Absorption Not Available Volume of distribution There is evidence that tauroursodeoxycholic acid crosses the blood brain barrier in humans.2 Protein binding Not Available Metabolism There is little biotransformation of tauroursodeoxycholic acid. It is partially deconjugated by intestinal microflora to form unconjugated bile acids.5, 6 Route of elimination Not Available Half-life Not Available Clearance Not Available Adverse Effects Improve decision support & research outcomes With structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates. Improve decision support & research outcomes with our structured adverse effects data.
Toxicity There is no information available regarding the LD 50 and overdose of tauroursodeoxycholic acid. Pathways Not Available Pharmacogenomic Effects/ADRs Not Available Drug Interactions This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately.
The absence of an interaction does not necessarily mean no interactions exist.
- Approved
- Vet approved
- Nutraceutical
- Illicit
- Withdrawn
- Investigational
- Experimental
- All Drugs
Drug | Interaction |
---|---|
Integrate drug-drug interactions in your software | |
Abciximab | The risk or severity of adverse effects can be increased when Abciximab is combined with Tauroursodeoxycholic acid. |
Acenocoumarol | The risk or severity of bleeding and bruising can be increased when Acenocoumarol is combined with Tauroursodeoxycholic acid. |
Acetylsalicylic acid | The risk or severity of adverse effects can be increased when Acetylsalicylic acid is combined with Tauroursodeoxycholic acid. |
Alteplase | The risk or severity of bleeding and bruising can be increased when Alteplase is combined with Tauroursodeoxycholic acid. |
Aluminium phosphate | Aluminium phosphate can cause a decrease in the absorption of Tauroursodeoxycholic acid resulting in a reduced serum concentration and potentially a decrease in efficacy. |
Aluminum chloride | Aluminum chloride can cause a decrease in the absorption of Tauroursodeoxycholic acid resulting in a reduced serum concentration and potentially a decrease in efficacy. |
Aluminum chlorohydrate | Aluminum chlorohydrate can cause a decrease in the absorption of Tauroursodeoxycholic acid resulting in a reduced serum concentration and potentially a decrease in efficacy. |
Aluminum hydroxide | Aluminum hydroxide can cause a decrease in the absorption of Tauroursodeoxycholic acid resulting in a reduced serum concentration and potentially a decrease in efficacy. |
Aluminum oxide | Aluminum oxide can cause a decrease in the absorption of Tauroursodeoxycholic acid resulting in a reduced serum concentration and potentially a decrease in efficacy. |
Aluminum sulfate | Aluminum sulfate can cause a decrease in the absorption of Tauroursodeoxycholic acid resulting in a reduced serum concentration and potentially a decrease in efficacy. |
Food Interactions No interactions found. Drug product information from 10+ global regions Our datasets provide approved product information including: dosage, form, labeller, route of administration, and marketing period. Access drug product information from over 10 global regions. Product Ingredients
Ingredient | UNII | CAS | InChI Key |
---|---|---|---|
Tauroursodeoxycholic acid dihydrate | U7XRV7RZ1I | 117609-50-4 | BNXLUNVCHFIPFY-GUBAPICVSA-N |
International/Other Brands Tauro (Teofarma) / Taurolite (Bio-Gen) Mixture Products
Name | Ingredients | Dosage | Route | Labeller | Marketing Start | Marketing End | Region | Image |
---|---|---|---|---|---|---|---|---|
Albrioza | Tauroursodeoxycholic acid (1 g / sachet) + Sodium phenylbutyrate (3 g / sachet) | Powder, for suspension | Oral | Amylyx Pharmaceuticals Inc. | 2022-07-29 | Not applicable | ||
Relyvrio | Tauroursodeoxycholic acid (1 g/1) + Sodium phenylbutyrate (3 g/1) | Powder, for suspension | Oral | Amylyx Pharmaceuticals Inc | 2022-09-29 | Not applicable |
Unapproved/Other Products
Name | Ingredients | Dosage | Route | Labeller | Marketing Start | Marketing End | Region | Image |
---|---|---|---|---|---|---|---|---|
TAUROLITE 250 MG 100 KAPSUL | Tauroursodeoxycholic acid (250 mg) | Capsule | Oral | BİO-GEN İLAÇ SAN.TİC.LTD.ŞTİ. | 2020-08-14 | Not applicable |
Drug Categories Chemical Taxonomy Provided by Classyfire Description This compound belongs to the class of organic compounds known as taurinated bile acids and derivatives. These are bile acid derivatives containing a taurine conjugated to the bile acid moiety.
Humans and other mammals
UNII 60EUX8MN5X CAS number 14605-22-2 InChI Key BHTRKEVKTKCXOH-LBSADWJPSA-N InChI InChI=1S/C26H45NO6S/c1-16(4-7-23(30)27-12-13-34(31,32)33)19-5-6-20-24-21(9-11-26(19,20)3)25(2)10-8-18(28)14-17(25)15-22(24)29/h16-22,24,28-29H,4-15H2,1-3H3,(H,27,30)(H,31,32,33)/t16-,17+,18-,19-,20+,21+,22+,24+,25+,26-/m1/s1 IUPAC Name 2-heptadecan-14-yl]pentanamido]ethane-1-sulfonic acid SMILES 12CC((C)CCC(=O)NCCS(O)(=O)=O)1(C)CC1()2()(O)C2()C(O)CC12C Synthesis Reference Zhuo, Chao; Feng, Wei; Wu, Da-jun; Xiong, Zhi-gang.
- Crosignani A, Battezzati PM, Setchell KD, Invernizzi P, Covini G, Zuin M, Podda M: Tauroursodeoxycholic acid for treatment of primary biliary cirrhosis. A dose-response study. Dig Dis Sci.1996 Apr;41(4):809-15. doi: 10.1007/BF02213140.
- Vang S, Longley K, Steer CJ, Low WC: The Unexpected Uses of Urso- and Tauroursodeoxycholic Acid in the Treatment of Non-liver Diseases. Glob Adv Health Med.2014 May;3(3):58-69. doi: 10.7453/gahmj.2014.017.
- Ahn TK, Kim KT, Joshi HP, Park KH, Kyung JW, Choi UY, Sohn S, Sheen SH, Shin DE, Lee SH, Han IB: Therapeutic Potential of Tauroursodeoxycholic Acid for the Treatment of Osteoporosis. Int J Mol Sci.2020 Jun 16;21(12). pii: ijms21124274. doi: 10.3390/ijms21124274.
- Lu Q, Jiang Z, Wang Q, Hu H, Zhao G: The effect of Tauroursodeoxycholic acid (TUDCA) and gut microbiota on murine gallbladder stone formation. Ann Hepatol.2021 Jul-Aug;23:100289. doi: 10.1016/j.aohep.2020.100289. Epub 2020 Nov 18.
- Setchell KD, Rodrigues CM, Podda M, Crosignani A: Metabolism of orally administered tauroursodeoxycholic acid in patients with primary biliary cirrhosis. Gut.1996 Mar;38(3):439-46. doi: 10.1136/gut.38.3.439.
- Invernizzi P, Setchell KD, Crosignani A, Battezzati PM, Larghi A, O’Connell NC, Podda M: Differences in the metabolism and disposition of ursodeoxycholic acid and of its taurine-conjugated species in patients with primary biliary cirrhosis. Hepatology.1999 Feb;29(2):320-7. doi: 10.1002/hep.510290220.
- AIFA: Tauro (Tauroursodeoxycholic Acid) Oral Capsules
- Health Canada Approved Drug Products: ALBRIOZA (sodium phenylbutyrate and ursodoxicoltaurine) Oral Powder for suspension
- FDA Approved Drug Products: RELYVRIO (sodium phenylbutyrate and taurursodiol) for oral suspension
External Links KEGG Compound C16868 PubChem Compound 9848818 PubChem Substance 175427112 ChemSpider 8024531 BindingDB 50236230 RxNav 2613950 ChEBI 80774 ChEMBL CHEMBL272427 ZINC ZINC000003914813 PDBe Ligand 5D5 Drugs.com Drugs.com Drug Page Wikipedia Ursodoxicoltaurine PDB Entries 5dlv / 5dlw Clinical Trials
Phase | Status | Purpose | Conditions | Count |
---|---|---|---|---|
4 | Unknown Status | Prevention | Gallstones | 1 |
3 | Active Not Recruiting | Treatment | Amyotrophic Lateral Sclerosis (ALS) | 1 |
3 | Active Not Recruiting | Treatment | TTR Cardiac Amyloidosis | 1 |
3 | Completed | Treatment | Cholestatic Liver Disease | 1 |
3 | Completed | Treatment | Primary Biliary Cholangitis | 1 |
3 | Enrolling by Invitation | Treatment | Amyotrophic Lateral Sclerosis (ALS) | 1 |
2 | Completed | Treatment | Alzheimer’s Disease (AD) | 1 |
2 | Completed | Treatment | Amyotrophic Lateral Sclerosis (ALS) | 1 |
2 | Completed | Treatment | Amyotrophic Lateral Sclerosis (ALS) / Central Nervous System Disorder / Diseases of the Nervous System / MND (Motor Neurone Disease) / Neurodegenerative Disorders / Neuromuscular Disorders / Spinal Cord Diseases / TDP-43 Proteinopathies | 1 |
2 | Completed | Treatment | Transthyretin Amyloidosis | 1 |
Manufacturers Not Available Packagers Not Available Dosage Forms
Form | Route | Strength |
---|---|---|
Powder, for suspension | Oral | |
Capsule | Oral | 150 MG |
Capsule | Oral | 250 MG |
Capsule, delayed release | Oral | 500 MG |
Tablet, extended release | Oral | 500 MG |
Prices Not Available Patents
Patent Number | Pediatric Extension | Approved | Expires (estimated) | Region |
---|---|---|---|---|
US10857162 | No | 2020-12-08 | 2033-12-24 | |
US10251896 | No | 2019-04-09 | 2033-12-24 | |
US9872865 | No | 2018-01-23 | 2033-12-24 | |
US11071742 | No | 2021-07-27 | 2033-12-24 | |
US11583542 | No | 2020-07-27 | 2040-07-27 |
State Solid Experimental Properties Not Available Predicted Properties
Property | Value | Source |
---|---|---|
Water Solubility | 0.00748 mg/mL | ALOGPS |
logP | 1.38 | ALOGPS |
logP | 1.1 | Chemaxon |
logS | -4.8 | ALOGPS |
pKa (Strongest Acidic) | -0.8 | Chemaxon |
pKa (Strongest Basic) | -0.32 | Chemaxon |
Physiological Charge | -1 | Chemaxon |
Hydrogen Acceptor Count | 6 | Chemaxon |
Hydrogen Donor Count | 4 | Chemaxon |
Polar Surface Area | 123.93 Å 2 | Chemaxon |
Rotatable Bond Count | 7 | Chemaxon |
Refractivity | 130.68 m 3 ·mol -1 | Chemaxon |
Polarizability | 56.75 Å 3 | Chemaxon |
Number of Rings | 4 | Chemaxon |
Bioavailability | 1 | Chemaxon |
Rule of Five | Yes | Chemaxon |
Ghose Filter | No | Chemaxon |
Veber’s Rule | No | Chemaxon |
MDDR-like Rule | Yes | Chemaxon |
Predicted ADMET Features
Property | Value | Probability |
---|---|---|
Human Intestinal Absorption | + | 0.9774 |
Blood Brain Barrier | + | 0.8416 |
Caco-2 permeable | – | 0.8957 |
P-glycoprotein substrate | Non-substrate | 0.5136 |
P-glycoprotein inhibitor I | Non-inhibitor | 0.6229 |
P-glycoprotein inhibitor II | Non-inhibitor | 0.7598 |
Renal organic cation transporter | Non-inhibitor | 0.8476 |
CYP450 2C9 substrate | Non-substrate | 0.7519 |
CYP450 2D6 substrate | Non-substrate | 0.7972 |
CYP450 3A4 substrate | Substrate | 0.654 |
CYP450 1A2 substrate | Non-inhibitor | 0.7814 |
CYP450 2C9 inhibitor | Non-inhibitor | 0.8625 |
CYP450 2D6 inhibitor | Non-inhibitor | 0.8685 |
CYP450 2C19 inhibitor | Non-inhibitor | 0.8426 |
CYP450 3A4 inhibitor | Non-inhibitor | 0.8612 |
CYP450 inhibitory promiscuity | Low CYP Inhibitory Promiscuity | 0.7175 |
Ames test | Non AMES toxic | 0.6103 |
Carcinogenicity | Non-carcinogens | 0.5359 |
Biodegradation | Not ready biodegradable | 0.972 |
Rat acute toxicity | 2.0310 LD50, mol/kg | Not applicable |
hERG inhibition (predictor I) | Weak inhibitor | 0.706 |
hERG inhibition (predictor II) | Inhibitor | 0.5549 |
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. ( 23092397 ) Mass Spec (NIST) Not Available Spectra
Spectrum | Spectrum Type | Splash Key |
---|---|---|
Predicted MS/MS Spectrum – 10V, Positive (Annotated) | Predicted LC-MS/MS | Not Available |
Predicted MS/MS Spectrum – 20V, Positive (Annotated) | Predicted LC-MS/MS | Not Available |
Predicted MS/MS Spectrum – 40V, Positive (Annotated) | Predicted LC-MS/MS | Not Available |
Predicted MS/MS Spectrum – 10V, Negative (Annotated) | Predicted LC-MS/MS | Not Available |
Predicted MS/MS Spectrum – 20V, Negative (Annotated) | Predicted LC-MS/MS | Not Available |
Predicted MS/MS Spectrum – 40V, Negative (Annotated) | Predicted LC-MS/MS | Not Available |
Does TUDCA detox the liver?
What do you know about your liver? Did you know that it’s one of your body’s largest and most important organs? The liver acts as a filter which catches toxins and waste and cleanses them from your system. Alcohol, fat, sugar, these are just a few of the things that the liver filters out.
Can I take NAC supplement before alcohol?
1. N-acetyl-cysteine (NAC) – N-acetylcysteine, also known as NAC, is one of the best supplements you can use to and the negative effects of alcohol on your body. NAC increases your body’s ability to produce glutathione, which is an antioxidant that can reduce the toxicity causing your painful hangover.