How does alcohol damage the stomach? – The stomach is the first organ to have long contact with alcohol. The stomach’s primary job is to store and mix food and drink that has been consumed.15 One-off and regular drinking can interfere with the functions of the stomach in a number of ways.16
Alcohol can affect stomach acid production. This can reduce the stomach’s ability to destroy bacteria that enter the stomach, which can allow potentially harmful bacteria to enter the upper small intestine.17 Mucous cells in the stomach lining protect the stomach wall from being damaged from the acid and digestive enzymes.18 A single heavy episode of drinking can damage the mucous cells in the stomach, and induce inflammation and lesions.19 High alcohol content beverages (more than 15% alcohol volume) can delay stomach emptying, which can result in bacterial degradation of the food, and cause abdominal discomfort.20
Contents
- 1 What proof will absorb more slowly because it irritates the stomach?
- 2 How does the body digest alcohol?
- 3 What happens if a large amount of alcohol is consumed over short of time?
- 4 What happens if you drink alcohol and don’t eat?
- 5 What are 2 ways alcohol affects the stomach?
- 6 Does anything get absorbed by the stomach?
What proof will absorb more slowly because it irritates the stomach?
Exception: alcohol in excess of 100-proof will absorb more slowly because it irritates the stomach.
What proof irritates the stomach?
First, we need to determine the proof of alcohol that irritates the stomach and causes it to absorb more slowly. The answer is 100-proof.
In what blank minutes after a drink is consumed all of the alcoholic content has probably been absorbed into the body?
Most of the alcohol from one drink will be absorbed into the bloodstream within 20 to 40 minutes of drinking.
How does the body digest alcohol?
Abstract – Alcohol is eliminated from the body by various metabolic mechanisms. The primary enzymes involved are aldehyde dehydrogenase (ALDH), alcohol dehydrogenase (ADH), cytochrome P450 (CYP2E1), and catalase. Variations in the genes for these enzymes have been found to influence alcohol consumption, alcohol-related tissue damage, and alcohol dependence.
The consequences of alcohol metabolism include oxygen deficits (i.e., hypoxia) in the liver; interaction between alcohol metabolism byproducts and other cell components, resulting in the formation of harmful compounds (i.e., adducts); formation of highly reactive oxygen-containing molecules (i.e., reactive oxygen species ) that can damage other cell components; changes in the ratio of NADH to NAD + (i.e., the cell’s redox state); tissue damage; fetal damage; impairment of other metabolic processes; cancer; and medication interactions.
Several issues related to alcohol metabolism require further research. Keywords: Ethanol-toacetaldehyde metabolism, alcohol dehydrogenase (ADH), aldehyde dehydrogenase (ALDH), acetaldehyde, acetate, cytochrome P450 2E1 (CYP2E1), catalase, reactive oxygen species (ROS), blood alcohol concentration (BAC), liver, stomach, brain, fetal alcohol effects, genetics and heredity, ethnic group, hypoxia The effects of alcohol (i.e., ethanol) on various tissues depend on its concentration in the blood (blood alcohol concentration ) over time.
- BAC is determined by how quickly alcohol is absorbed, distributed, metabolized, and excreted.
- After alcohol is swallowed, it is absorbed primarily from the small intestine into the veins that collect blood from the stomach and bowels and from the portal vein, which leads to the liver.
- From there it is carried to the liver, where it is exposed to enzymes and metabolized.
The rate of the rise of BAC is influenced by how quickly alcohol is emptied from the stomach and the extent of metabolism during this first pass through the stomach and liver (i.e., first-pass metabolism ). BAC is influenced by environmental factors (such as the rate of alcohol drinking, the presence of food in the stomach, and the type of alcoholic beverage) and genetic factors (variations in the principal alcohol-metabolizing enzymes alcohol dehydrogenase and aldehyde dehydrogenase ).
The alcohol elimination rate varies widely (i.e., three-fold) among individuals and is influenced by factors such as chronic alcohol consumption, diet, age, smoking, and time of day ( Bennion and Li 1976 ; Kopun and Propping 1977 ). The consequent deleterious effects caused by equivalent amounts of alcohol also vary among individuals.
Even after moderate alcohol consumption, BAC can be considerable (0.046 to 0.092 gram-percent ; in the 10- to 20-millimolar 1 range). Alcoholreadily diffuses across membranes and distributes through all cells and tissues, and at these concentrations, it can acutelyaffect cell function by interacting with certain proteins and cell membranes.
As explained in this article, alcohol metabolism also results in the generation of acetaldehyde, a highly reactive and toxic byproduct that may contribute to tissue damage, the formation ofdamaging molecules known as reactive oxygen species (ROS), and a change in the reduction–oxidation (or redox) state of liver cells.
Chronic alcohol consumption and alcohol metabolism are strongly linked to several pathological consequences and tissue damage. Understanding the balance of alcohol’s removal and the accumulation of potentially damaging metabolic byproducts, as well as how alcohol metabolism affects other metabolic pathways, is essentialfor appreciating both the short-term and long-term effects of the body’s response to alcohol intake.
Why is alcohol absorbed by the body much faster than food?
Factors Affecting Intoxication – Alcohol affects each person differently. It also affects the same person differently on different occasions. The following are some of the factors that affect how quickly a person will become intoxicated: Gender – Alcohol affects men and women differently.
In some women, the effects of alcohol tend to be stronger and last longer. This may be due to women having higher levels of estrogen, body fat, and lower levels of body water than men. All of which limits the amount of alcohol absorbed into tissues, thus remaining in the bloodstream. Men, on the other hand, typically have more of the enzymes that break down alcohol in the stomach before being absorbed into their bloodstream.
Mood – Alcohol exaggerates the mood of a person. An individual who is depressed may become severely depressed while drinking. People who are fatigued or stressed become intoxicated more quickly than people who are rested and relaxed. Physical, mental, or emotional exhaustion will increase the impairment caused by alcohol.
- Food in the stomach – Food slows down the rate of intoxication because food causes the pyloric valve at the bottom of the stomach to close while digestion takes place.
- This keeps alcohol from entering the small intestine, where most of it is absorbed.
- The best foods for slowing intoxication are greasy, high-protein and fatty foods because they are more difficult to digest and stay in the stomach longer.
For example: meat balls, chicken wings, cheese, pizza, dips, fried foods, nachos, and beef tacos. Amount of alcohol consumed – The more alcohol a person consumes, the more it accumulates in the blood, increasing intoxication. The liver can only get rid of about one drink per hour.
- Speed of consumption – A person who drinks rapidly or gulps drinks becomes intoxicated faster than a person who sips or drinks slowly because they ingest a larger amount of alcohol over the same period.
- Tolerance to alcohol – Tolerance is the body’s ability to adapt to toxic substances like alcohol.
- Tolerance varies from person to person, but some have a naturally high tolerance, while others may develop high tolerance through habitual drinking.
A person with a high tolerance may appear sober to others when they are extremely impaired. Physical condition – A person who is out of shape becomes intoxicated more quickly than a person who is muscular. Fat does not absorb blood, water, or alcohol, while muscle does.
- Medication/Drugs – Mixing alcohol and medications/drugs together can lead to serious physical, behavioral, and health complications.
- Not only can alcohol and drugs increase the effects of each substance, they can also trigger dangerous interactions.
- The side effects of combining alcohol with drugs may range from mere discomfort to life-threatening reactions.
Alcohol should not be sold to a person who has taken any drug. Carbonation – Carbonated alcoholic drinks increase the rate of alcohol absorption. This is because the pressure inside the stomach and small intestine force the alcohol to be absorbed more quickly into the bloodstream.
What in the stomach will slow down absorption of alcohol?
Absorbing – Once alcohol is swallowed, it is not digested like food. First, a small amount is absorbed directly by the tongue and mucosal lining of the mouth. Once in the stomach, alcohol is absorbed directly into your blood stream through the tissue lining of the stomach and small intestine.
- Food in the stomach can inhibit the absorption of alcohol in two ways: First, it physically obstructs the alcohol from coming in contact with the stomach lining.
- Food can either absorb alcohol, or simply “take up space” so the alcohol does not enter the bloodstream through contact with the wall of the stomach.
Second, food in the stomach will prevent alcohol from passing into the duodenum, which is the upper portion of the small intestine. The surface area of the small intestine is very large (about the size of a tennis court), so alcohol has more access to enter the bloodstream once it leaves the stomach.
Why does beer upset my stomach?
Alcohol can increase the amount of acid in your stomach. This can irritate the lining of your stomach. Drinking too much alcohol can cause:
gastritisulcers reflux (heartburn)
Stomach problems can make you feel sick, vomit or lose your appetite. If your stomach lining is inflamed, you might not absorb nutrients from food.
Which is better for your stomach wine or beer?
Which alcohols affect your stomach the least? – According to Purdy, the best alcohols for a sensitive stomach are those with lower alcohol and sugar contents, including:
Light lager: These beers have fewer calories, plus a lower alcohol content. Dry red wine: These wines offer potential gut health benefits and have low residual sugar levels. Examples include chianti, Bordeaux, tempranillo, barbera, and cabernet franc. Vodka and gin: Vodka and gin are much lower in FODMAPs than most other spirits. That said, they do have a higher ABV, which could counter the benefits of being low in FODMAPs. Wine spritzer: Wine can be tricky, as the lowest-alcohol wines tend to have the most sugar — and those with less sugar have higher alcohol content. Still, you can always make a wine spritzer by adding seltzer to dilute the drink and cut down the alcohol content.
Where does the alcohol go that is so harmful to the body within 90 seconds of entering the body?
The Alcohol Pathway Alcohol is a mood altering depressant drug that can reach every cell in your body. When alcohol is swallowed it is not digested like food; instead, a small amount is immediately absorbed directly into your blood stream by the lining of your mouth and stomach.
- The rest of the alcohol is rapidly absorbed in the small intestine.
- Within 90 seconds (a healthy circulation rate) it will affect all the organs and systems in your body, crossing even the blood-brain barrier, which normally keeps harmful substances away from the brain.
- Your body tries immediately to metabolize (break down) the alcohol into non-harmful substances (water, carbon dioxide and energy).
Ten percent of the alcohol is eliminated through sweat, breathing and urine. Enzymes in you stomach and liver must detoxify the rest. This happens at a constant rate of one-half ounce per hour (about half a standard drink). Nothing with increase this rate and not all people can detoxify that much alcohol in an hour.
- When the rate of alcohol consumption exceeds the rate of detoxification, the amount of alcohol in the bloodstream continues to build, with increasingly detrimental effects.
- Vomiting and loss of consciousness, the body’s last defenses against an alcohol overdose, may occur prior to severe impairment of the brain.
However, if alcohol is consumed in large quantities and quickly (drinking games and multiple shots) these life saving mechanisms cannot stop the blood alcohol levels from climbing and death can occur from acute alcohol poisoning Affecting Factors How alcohol affects you will depend on how much is in your bloodstream- you blood alcohol concentration (BAC).
- The BAC determines how much intoxication (depression of your nervous system) will occur.
- Many factors affect your rate of intoxication, including: The amount and speed of consumption – if alcohol is consumed slowly, it allows the body to metabolize it and limit accumulation in the bloodstream.
- A full or empty stomach – food, water and fruit juice dilute alcohol and will help to slow down its absorption into the bloodstream (by up to 50%).
Carbonation works to speed absorption Body weight and composition – the body is 60% water and as fat holds less water than muscle, those who are leaner and heavier have a higher water content to dilute the alcohol, so the effects of alcohol are less pronounced than in a lighter person who drinks the same amount or those with a greater percentage of body weight.
- Gender – women absorb about a third more alcohol into their blood stream than men as they have less of the metabolizing enzyme, alcohol dehydrogenase.
- Setting, mood or atmosphere- what you expect, the setting or location, your mental state and other drugs being used, can also alter alcohol’s effects.
If you are tired, upset, depressed, excited inexperienced you are more susceptible. Many people become intoxicated on less alcohol merely because that have that expectation before they begin drinking. Age- as people get older they are affected more by alcohol Tolerance- the bodies of experienced drinkers have adapted to alcohol being present in their systems, so it may take longer and more alcohol to feel impaired.
Short-Term Effects – Alcohol increases stomach secretions, which could cause heartburn. Kidneys increase urinary output, contributing to dehydration and a hangover. Blood vessels dilate in the skin causing loss of body heat despite a feeling of warmth, which could be dangerous in situations of extreme cold.
In a study involving non-alcoholic volunteers, acute intake of even small amounts of alcohol (1-2 oz.) led to accumulations of fat in liver cells. Alcohol may increase sexual desire but decreases sexual performance by inhibiting the physical responses of the sexual organs. Long-Term Effects Moderate and occasional use of alcohol in a healthy person is likely to cause health problems.
The possible benefits of alcohol consumption have also been studied. One or two drinks a day has been shown to have a protective effect against heart disease, at least in men over the age of 40 year and postmenopausal women. Because heavy drinking is harmful to health and can lead to violence and accidents, encouraging alcohol consumption seems like a poor preventative health measure.
- Safer alternatives include eating sensibly, exercising regularly, and quitting smoking.
- The harmful physical and psychological effects of long-term excessive use are many and can be fatal.
- Women are more susceptible to these effects than men.
- They can result from the direct toxic effects of alcohol or be secondary to the lack of nutrition, use of other drugs, and other lifestyle factors.
The effects of long-term alcohol use on the various organs and tissues of the body depend on the amount of alcohol consumed and the number of years excess drinking has occurred. Diet and health care also have an effect. People vary greatly in how much alcohol they can tolerate before physical damage occurs.
Appearance Alcohol is a carbohydrate with non-nutritional calories that quickly add up. It has so little in the way of nutrition and vitamins that it could never replace food in the human diet. When you abuse alcohol, you tend to be undernourished- making you hair dry, giving you cracked lips, aggravating acne, making your eyes look glassy, and giving you skin a puffy, broken vein look.
According to researchers, more than one or two drinks a week promotes aging. Nervous System Research finding show youth who drink can have a significant reduction in learning and memory. The brain goes through dynamic change during adolescence, and alcohol can seriously damage long and short-term growth processes.
Frontal lobe development and the refinement of pathways and connections continue until age 16, and a high rate of energy is used as the brain matures until age 20. Damage from alcohol at this time can be long-term and irreversible. In addition, short-term or moderate drinking impairs learning and memory far more in youth than adults.
Adolescents only need half as much alcohol as adults to suffer from the same negative effects. Alcohol abuse can also seriously disrupt sleep and cause movement disorders, damage to peripheral nerves and an increased risk of serious complications following head injury.
- Gastrointestinal Tract and Digestive System Serious disease of the liver and pancreas, and damage to the stomach and intestines can result from excessive use of alcohol.
- Chronic alcohol abuse is the single most frequent cause of illness and death from liver cells from functioning (detoxifying blood).
Eventually scar tissue can develop and cirrhosis- an irreversible and fatal condition whereby liver tissue degenerates and dies. A severe bout of heavy drinking (alcoholic hepatitis) can also cause the death of liver cells. Pancreatic disease and the onset of diabetes may occur.
- Alcohol’s irritation of the stomach, increases acidity; this excess acid burns through the protective mucous lining causing ulcers on the stomach and intestinal walls.
- Bleeding from the stomach, from enlarged veins around the esophagus, diarrhea and malabsorbtion of food can all occur in heavy drinkers.
Cardiovascular System Alcohol is linked to an increased risk of high blood pressure, abnormal heartbeat rhythms, deterioration of the heart muscle and heart disease. Anemia is common in people who abuse alcohol Reproductive system, and other Hormonal and Metabolic Effects.
- In men, chronic ingestion of excess alcohol may lead to impotence, sterility, atrophy of the testes, and enlargement of the breasts.
- Early menopause and menstrual irregularities are common in women who drink excessively.
- Excess output of hormones from the adrenal gland can occur and low levels of sex hormones can lead to premature bone less (osteoporosis).
Acute alcohol abuse can cause low blood sugar, which is of particular concern for diabetic patients. Ketoacidosis, a condition where the blood in the body becomes too acidic, can also be caused by excess alcohol use. Immune System and Cancer-producing Effects Depression of the immune system by chronic alcohol abuse results in predisposition to infections such as pneumonia and tuberculosis, and cancer.
In addition, increased risk of infection could occur if loss of judgement and inhibitions during intoxication resulted in unsafe sexual practices and in drug users sharing needles. Cancer of the throat, voice box (larynx), mouth and esophagus, and liver are most frequently associated with excessive use of alcohol.
Less conclusive evidence of increased cancer exists for the stomach, large bowel, pancreas, lung, urinary tract and breast.
What happens if a large amount of alcohol is consumed over short of time?
Overview – Alcohol poisoning is a serious — and sometimes deadly — result of drinking large amounts of alcohol in a short period of time. Drinking too much too quickly can affect breathing, heart rate, body temperature and gag reflex. In some cases, this can lead to a coma and death.
What percentage of alcohol is absorbed by the small intestine?
How does alcohol move through the body? – Once swallowed, a drink enters the stomach and small intestine, where small blood vessels carry it to the bloodstream. Approximately 20% of alcohol is absorbed through the stomach and most of the remaining 80% is absorbed through the small intestine.
Alcohol is metabolized by the liver, where enzymes break down the alcohol. Understanding the rate of metabolism is critical to understanding the effects of alcohol. In general, the liver can process one ounce of liquor (or one standard drink) in one hour. If you consume more than this, your system becomes saturated, and the additional alcohol will accumulate in the blood and body tissues until it can be metabolized.
This is why pounding shots or playing drinking games can result in high blood alcohol concentrations that last for several hours. For an interactive look at alcohol moving through the human body, click here
What enzyme breaks down alcohol?
The Chemical Breakdown of Alcohol –
Acetaldehyde: a toxic byproduct— Much of the research on alcohol metabolism has focused on an intermediate byproduct that occurs early in the breakdown process—acetaldehyde. Although acetaldehyde is short lived, usually existing in the body only for a brief time before it is further broken down into acetate, it has the potential to cause significant damage.
This is particularly evident in the liver, where the bulk of alcohol metabolism takes place (4). Some alcohol metabolism also occurs in other tissues, including the pancreas (3) and the brain, causing damage to cells and tissues (1). Additionally, small amounts of alcohol are metabolized to acetaldehyde in the gastrointestinal tract, exposing these tissues to acetaldehyde’s damaging effects (5).
In addition to its toxic effects, some researchers believe that acetaldehyde may be responsible for some of the behavioral and physiological effects previously attributed to alcohol (6). For example, when acetaldehyde is administered to lab animals, it leads to incoordination, memory impairment, and sleepiness, effects often associated with alcohol (7).
What does 80 proof alcohol contain?
Question: What does proof mean when referring to alcoholic beverages? Answer: Proof is defined as twice the alcohol (ethanol) content by volume. For example, a whisky with 50% alcohol is 100-proof whiskey. Anything 120-proof would contain 60% alcohol, and 80-proof means 40% of the liquid is alcohol.
What happens if you drink alcohol and don’t eat?
Why drunkorexia is so damaging – Effectively, substituting food with alcohol means the body is missing out on important nutrients. Alcohol is no replacement for food; it offers no nutritional benefits and it’s full of empty calories. The only thing that people are doing in this scenario is depleting the body of essential vitamins and minerals because even with the pre-drinking starvation tactic, excessive drinking can still lead to weight gain.
Alcohol reduces the amount of fat our body burns for energy and, no matter how little a person eats before a drinking session, it’s still likely to affect the scales the next morning. Drinking on an empty stomach also means a person will become drunk much quicker than they normally would and are more likely to get sick as the body struggles to process the alcohol.
Common side effects of drinking without eating beforehand include:
Impaired co-ordination Stomach pain Slowed brain function Dizziness Mental confusion Slurred speech Listlessness (showing little interest in things) Mood swings Constipation
One thing that ‘drunkorexics’ won’t have considered is that regardless of how many or how few calories they have consumed in the run-up to a drinking session, alcohol consumption still contributes to high blood pressure, liver disease and cancer all the same.
What is the best type of food to slow alcohol absorption?
4 foods to eat before drinking alcohol to line your stomach and avoid a hangover Eggs and yogurt are rich in protein, which can slow alcohol absorption. Alexander Spatari
Eating a nutritious meal before drinking alcohol can help you avoid a hangover or getting too drunk. Foods high in protein and healthy fats, like yogurt and salmon, can help slow alcohol absorption. Avocados and bananas also contain plenty of potassium, which you might lose after drinking.,
Just because it’s r doesn’t mean you have to accept a season of and pushing your alcohol tolerance to the limit.With the return of happy hours and nights out, now is the time to start drinking smarter.Choosing a and alternating alcoholic drinks with water can help minimize your likelihood of waking up in a world of pain after drinking.
But before you get to the bar, you can prepare yourself for a night of drinking by eating a meal rich in protein, potassium, and healthy fats. Filling up on food will help you pace your drinking and ensure that the alcohol doesn’t go straight to your head. Bananas are full of potassium and water. Westend61/Getty Images
What are 2 ways alcohol affects the stomach?
How does alcohol damage the stomach? – The stomach is the first organ to have long contact with alcohol. The stomach’s primary job is to store and mix food and drink that has been consumed.15 One-off and regular drinking can interfere with the functions of the stomach in a number of ways.16
Alcohol can affect stomach acid production. This can reduce the stomach’s ability to destroy bacteria that enter the stomach, which can allow potentially harmful bacteria to enter the upper small intestine.17 Mucous cells in the stomach lining protect the stomach wall from being damaged from the acid and digestive enzymes.18 A single heavy episode of drinking can damage the mucous cells in the stomach, and induce inflammation and lesions.19 High alcohol content beverages (more than 15% alcohol volume) can delay stomach emptying, which can result in bacterial degradation of the food, and cause abdominal discomfort.20
How do you make alcohol easier on your stomach?
Drinks To Avoid If You Have a Sensitive Stomach – If you find that alcoholic drinks upset your stomach, here are a few things to avoid:
Cocktails that use mixers containing a lot of sugarCocktails that use acidic ingredients such as tomato or citrus juicesDrinks with peppermint, chocolate, or coffee if you have acid reflux
Carbonated beverages are on the maybe list. If you have issues with bloating, skip the bubbles. But if your stomach is temporarily feeling upset, try club soda or ginger beer as a mixer with your of choice.
Why do weak acids absorb better in stomach?
Ionization – The gastrointestinal tract is lined with epithelial cells, Drugs must pass through or permeate these cells to be absorbed into the bloodstream, Cell membranes may act as barriers to some drugs. They are essentially lipid bilayers which form semipermeable membranes,
Pure lipid bilayers are generally permeable only to small, uncharged solutes. Hence, whether or not a molecule is ionized will affect its absorption, since ionic molecules are charged. Solubility favors charged species, and permeability favors neutral species. Some molecules have special exchange proteins and channels to facilitate movement from the lumen into the circulation.
Ions cannot passively diffuse through the gastrointestinal tract because the epithelial cell membrane is made up of a phospholipid bilayer, comprising two layers of phospholipids in which the charged hydrophilic heads face outwards and the uncharged hydrophobic fatty acid chains are in the middle of the layer.
The fatty acid chains repel ionized, charged molecules. This means that the ionized molecules cannot pass through the intestinal membrane and be absorbed. The Henderson-Hasselbalch equation offers a way to determine the proportion of a substance that is ionized at a given pH. In the stomach, drugs that are weak acids (such as aspirin ) will be present mainly in their non-ionic form, and weak bases will be in their ionic form.
Since non-ionic species diffuse more readily through cell membranes, weak acids will have a higher absorption in the highly acidic stomach, However, the reverse is true in the basic environment of the intestines—weak bases (such as caffeine ) will diffuse more readily since they will be non-ionic.
- This aspect of absorption has been targeted by medicinal chemists.
- For example, they may choose an analog that is more likely to be in a non-ionic form.
- Also, the chemists may develop prodrugs of a compound—these chemical variants may be more readily absorbed and then metabolized by the body into the active compound.
However, changing the structure of a molecule is less predictable than altering dissolution properties, since changes in chemical structure may affect the pharmacodynamic properties of a drug. The solubility and permeability of a drug candidate are important physicochemical properties the scientist wants to know as early as possible.
Do acidic drugs tend to be better absorbed in the stomach?
Abstract – The human stomach is capable of absorbing most acidic drugs and the very weakly basic drugs. Salicylic acid, aspirin, thiopental, secobarbital and antipyrine, which are undissociated in the acidic gastric contents, were readily absorbed. Phenol red, quinine, ephedrine and aminopyrine, which are almost completely ionized in acid solution were not absorbed.
What can be absorbed by the stomach?
Three substances are absorbed through the stomach water, Simple sugar like Glucose, and alcohol like ethanol.
Does anything get absorbed by the stomach?
VIVO Pathophysiology Digestive System > Stomach The stomach absorbs very few substances, although small amounts of certain lipid-soluble compounds can be taken up, including aspirin, other non-steroidal anti-infammatory drugs, and ethanol. Notably, these substances are also well-recognized causes of gastric irritation and their use (especially overuse) is commonly associated with development of gastritis and gastric ulcers. Gastric Secretions One Meal in the Life of the Stomach Send comments to [email protected]