Key takeaways: You shouldn’t mix metronidazole (Flagyl) and alcohol. The mixture of metronidazole and alcohol could lead to nausea, vomiting, fast heart beat, and flushing of the face. You should avoid alcohol while taking metronidazole and for at least 3 days after your last dose.
- 0.1 Can I have one alcoholic drink with metronidazole?
- 1 Does Flagyl treat infection?
- 2 How quickly does metronidazole work?
- 3 How long does 500 mg of Flagyl stay in your system?
- 4 Can you have alcohol in food while taking metronidazole?
- 5 Is 500 mg of Flagyl a lot?
- 6 Is Flagyl 3 times a day?
- 7 What not to mix with Flagyl?
What should I do if I drank alcohol with Flagyl?
First, do not drink any more alcohol. Switch to water and avoid alcoholic drinks for 3 days after your last dose of Flagyl. If you become nauseous, sip water and avoid sudden movement. If you feel lightheaded or dizzy, sit down to avoid falling.
Does Flagyl still work if you drink?
Understanding the Risks of Mixing Flagyl and Alcohol – The primary risk that comes with mixing Flagyl and alcohol is not that the antibiotic would be ineffective; rather, the main danger is that the interaction between the two can have severe physical side effects.
Even when taken properly, metronidazole (Flagyl) may result in negative side effects such as diarrhea, tingling or numb hands and feet, mood swings, light sensitivity, coordination and concentration problems, flu-like symptoms, and more. The reaction between Flagyl and alcohol is similar to the effects of Antabuse, which is a drug that treats alcoholism by making patients highly sensitive to alcohol consumption.
Both result in the patient feeling very sick after consuming even a small amount of alcohol. If a patient consumes alcohol while taking metronidazole, the list of negative side effects becomes more severe—even fatal. Symptoms associated with mixing Flagyl and alcohol include:
- Flushed face
- Abdominal pain
- Throbbing in head and neck
- Difficulty breathing
- Nausea and vomiting
- Dropping blood pressure
- Rapid heart rate
- Liver damage
- Heart attack or heart failure
- Loss of consciousness
It’s important to note that negative reactions don’t occur only while taking Flagyl and alcohol at the same time. Symptoms can occur even if you drink several hours after taking the medication, or even the next day. Flagyl is usually taken over the course of 10 days, and it is best to wait a minimum of 72 hours after taking the last dose before consuming alcohol.
Can I have one alcoholic drink with metronidazole?
The potential interactions of antimicrobials with alcohol are best considered in three categories, all of which have patient implications: (i) alterations in pharmacokinetics and pharmacodynamics (PK/PD) of the antimicrobial and/or alcohol, (ii) changes in antimicrobial efficacy, and (iii) development of toxicity.
- PK/PD were considered together to describe the effect of drug and alcohol on absorption, distribution, metabolism, and excretion (PK) and the resultant effect of this interaction on the host (PD).
- Concomitant use of alcohol with antimicrobials is believed to either decrease efficacy or lead to toxicity/ADR ( 6, 7 ).
The classic example of a feared medication interaction with alcohol is the “disulfiram-like” reaction. Symptoms may include facial flushing, nausea, headache, vomiting, chest pain, vertigo, sweating, thirst, blurred vision, weakness, confusion, and hypotension ( 8 ).
Furthermore, alcohol can cause hepatic stress or injury with or without the use of potentially hepatotoxic medications. These concerns may be responsible for alcohol warnings that accompany many antimicrobials, but what are the data and strength of support for these warnings? The goal of this review was to summarize existing data, which in turn generates insights into the origin of these warnings.
This review may also be helpful in assessing a patient who presents with an adverse drug effect which may or may not have been due to an alcohol and antibiotic interaction. Although we do not want to encourage alcohol use, it is important for health care professionals to be informed on this common clinical scenario, ensuring that patients can be educated and questions can be addressed in an evidence-based manner.
How long after taking metronidazole can I drink alcohol?
Metronidazole and tinidazole – It’s best to completely avoid alcohol while taking:
metronidazole – an antibiotic sometimes used for dental or vaginal infections, skin infections, infected leg ulcers and pressure sorestinidazole – an antibiotic sometimes used to treat many of the same infections as metronidazole, as well as to help clear bacteria called Helicobacter pylori (H. pylori) from the gut
Continue to avoid alcohol for 48 hours after you stop taking metronidazole and 72 hours after you stop taking tinidazole. Drinking alcohol with metronidazole or tinidazole can cause very unpleasant side effects, such as:
feeling and being sickstomach painhot flushesa fast or irregular heartbeatheadachesfeeling dizzyfeeling drowsy
Is Flagyl a strong antibiotic?
Bottom Line. Flagyl is an antibiotic that is particularly effective at treating infections caused by susceptible anaerobic bacteria and parasites.
Does Flagyl treat infection?
My Account Area – The Patient Information Leaflet (PIL) is the leaflet included in the pack with a medicine. Last updated on emc: 14 Jun 2023 FLAGYL TM 400MG TABLETS Metronidazole Is this leaflet hard to see or read? Phone 0800 035 2525 for help
Keep this leaflet. You may need to read it again.If you have further questions, please ask your doctor or pharmacist.This medicine has been prescribed for you only. Do not pass it on to others. It may harm them, even if their signs of illness are the same as yours.If you get any side effects, talk to your doctor or pharmacist. This includes any possible side effects not listed in the leaflet. See section 4.
1. What Flagyl is and what it is used for 2. What you need to know before you take Flagyl 3. How to take Flagyl 4. Possible side effects 5. How to store Flagyl 6. Contents of the pack and other information The name of this medicine is Flagyl 400mg Tablets (called Flagyl in this leaflet).
Treat infections of the blood, brain, lung, bones, genital tract, pelvic area, stomach and intestinesTreat gum ulcers and other dental infectionsTreat infected leg ulcers and pressure soresPrevent infections after surgery
If you need any further information on your illness, speak to your doctor.
You are allergic (hypersensitive) to metronidazole, nitroimidazoles (e.g. tinidazole) or any of the other ingredients of this medicine (listed in section 6). Signs of an allergic reaction include: a rash, swallowing or breathing problems, swelling of your lips, face, throat or tongue.
Do not take Flagyl if any of the above apply to you. If you are not sure, talk to your doctor or pharmacist before taking Flagyl. Talk to your doctor or pharmacist before taking Flagyl if:
You have or have ever had a liver problemYou are having kidney dialysis (see section 3: ‘People having kidney dialysis’)You have a disease of the nervous system
If you are not sure if any of the above apply to you, talk to your doctor or pharmacist before taking your medicine. Do this even if they have applied in the past. Tell your doctor immediately and stop taking Flagyl if you develop: stomach pain, anorexia (loss of appetite), nausea (feeling sick), vomiting (being sick), fever, malaise, fatigue, vertigo (spinning sensation), jaundice, dark urine, putty or mastic-coloured stools or itching.
- Cases of severe liver toxicity/acute liver failure, including cases with a fatal outcome, in patients with Cockayne syndrome have been reported with Flagyl.
- If you are affected by Cockayne syndrome, your doctor should also monitor your liver function frequently while you are being treated with Flagyl and afterwards.
Serious skin reactions including Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), acute generalised exanthematous pustulosis (AGEP) have been reported with the use of Flagyl:
SJS/TEN can appear initially as reddish target-like spots or circular patches often with central blisters on the trunk. Also, ulcers of the mouth, throat, nose, genitals and eyes (red and swollen eyes) can occur. These serious skin rashes are often preceded by fever and/or flu-like symptoms. The rashes may progress to widespread peeling of the skin and life-threatening complications or be fatal.AGEP appears at the initiation of treatment as a red, scaly widespread rash with bumps under the skin and blisters accompanied by fever. The most common location: mainly localised on the skin folds, trunk, and upper extremities.
The highest risk for occurrence of serious skin reactions is within one week, typically, within 48 hours after start of treatment. If you develop a serious rash or another of these skin symptoms, stop taking Flagyl and contact your doctor or seek medical attention immediately.
Tell your doctor or pharmacist if you are taking, have recently taken or might take any other medicines. This includes medicines obtained without a prescription, including herbal medicines. This is because Flagyl can affect the way some other medicines work. Also, some other medicines can affect the way Flagyl works.
In particular tell your doctor if you are taking any of the following medicines:
Medicines used to thin the blood such as warfarinLithium for mental illnessPhenobarbital or phenytoin for epilepsy5-fluorouracil for cancerBusulfan for leukaemia (cancer of the blood cells)Ciclosporin to prevent the rejection of organs after transplantDisulfiram for alcoholism
If you are not sure, talk to your doctor or pharmacist before taking Flagyl. Do not drink any alcohol while you are taking Flagyl and for 48 hours after finishing your course. Drinking alcohol while using Flagyl might cause unpleasant side effects, such as feeling sick (nausea), being sick (vomiting), stomach pain, hot flushes, very fast or uneven heartbeat (palpitations) and headache.
You are pregnant, might become pregnant or think you may be pregnant. Flagyl should not be taken during pregnancy unless considered absolutely necessary.You are breast-feeding. It is better not to take Flagyl if you are breast-feeding. This is because small amounts may pass into the mother’s milk.
If you are pregnant or breast-feeding, think you may be pregnant or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine. While using Flagyl you may feel dizzy or experience vertigo (spinning sensation), confusion, hallucinations (seeing or hearing things that are not there), convulsions (fits) or temporary eyesight problems (such as blurred or double vision).
If this happens, do not drive or use any machinery or tools. Your doctor may wish to carry out some tests if you have been using this medicine for more than 10 days. If you are going to have a blood test, tell the doctor or nurse performing the test that you are using Flagyl. Flagyl can affect the results of some blood tests.
If you have any further questions on the use of this medicine, ask your doctor or pharmacist. Always take this medicine exactly as your doctor or pharmacist has told you. It is important to finish a full course of treatment. The length of a course will depend on your needs and the illness being treated.
Swallow the tablets whole with a drink of water.Do not crush or chew the tablets.Take these tablets during or just after a meal.The dose of Flagyl will depend on your needs and the illness being treated.The length of your treatment will depend on the type of illness you have and how bad it is.
The recommended dose is: Adults
The initial dose is 800mg.After 8 hours take another dose of 400mg and repeat this dose every 8 hours.
Your doctor will work out how much your child should take depending on their weight.Repeat the dose every 8 hours.If your child is a baby under 8 weeks of age, your doctor will give them one daily dose or two separate doses 12 hourly.
Start taking Flagyl Tablets 24 hours before your operation.Take 400 mg of Flagyl every 8 hours.After the operation you may be given Flagyl either through a drip into a vein or rectally as a suppository until you are able to take tablets again.
Give your child Flagyl Tablets 1-2 hours before their operation.Your doctor will work out how much your child should take depending on their weight.After the operation your child may be given Flagyl either through a drip into a vein or rectally as a suppository until they are able to take tablets again.
For treatment of other infections caused by parasites and some bacteria your doctor will decide how much Flagyl you need to take and how often. This will depend on your illness and how bad it is. The pharmacist’s label on the packaging will tell you how many tablets to take and how often to take them.
Kidney dialysis removes Flagyl from your blood. If you are having kidney dialysis you must take this medicine after your dialysis treatment. Your doctor may tell you to use a lower dose or to take the medicine less often. If you take more Flagyl than you should, tell your doctor or go to your nearest hospital casualty department straight away.
Take the pack and any tablets left with you. This is so the doctor knows what you have taken. If you forget to take Flagyl, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose. Do not take a double dose to make up for a forgotten dose.
You have an allergic reaction. The signs may include: swelling of the hands, feet, ankles, face, lips or throat which may cause difficulty in swallowing or breathing, an itchy, lumpy rash (hives) or nettle rash (urticaria).A serious but very rare side effect is a brain disease (encephalopathy). Symptoms vary but you might get a fever, stiff neck, headache, or see or hear things that aren’t there. You might also have problems using your arms and legs, problems with speaking or feel confused.You develop skin rashes including Stevens-Johnson syndrome or toxic epidermal necrolysis. These can appear as reddish target-like spots or circular patches often with central blisters on the trunk, skin peeling, ulcers of the mouth, throat, nose, genitals and eyes and can be preceded by fever and flu-like symptoms. Stop using Flagyl if you develop these symptoms and contact your doctor or seek medical attention immediately. See also section 2,You develop a red, scaly widespread rash with bumps under the skin and blisters accompanied by fever at the initiation of treatment (acute generalised exanthematous pustulosis). Stop using Flagyl if you develop these symptoms and contact your doctor or seek medical attention immediately. See also section 2. Yellowing of the skin and eyes. This could be due to a liver problem (jaundice).Unexpected infections, mouth ulcers, bruising, bleeding gums, or severe tiredness. This could be caused by a blood problem.Severe stomach pain which may reach through to your back (pancreatitis)
Very rare (affects less than 1 in 10,000 people)
Fits (convulsions)Mental problems such as feeling confused and seeing or hearing things that are not there (hallucinations)Problems with your eyesight such as blurred or double visionSkin rash or flushingHeadacheDarkening of the urineFeeling sleepy or dizzyPains in the muscles or jointsLiver problems including life-threatening liver failure (hepatocellular liver injury)
Not known (frequency cannot be estimated from the available data)
Numbness, tingling, pain, or a feeling of weakness, in the arms or legsUnpleasant taste in the mouth, furred tongueFeeling sick (nausea), being sick (vomiting), upset stomach, stomach pain or diarrhoeaLoss of appetiteFeverFeeling depressedPain in your eyes (optic neuritis)A group of symptoms together including: fever, nausea, vomiting, headache, stiff neck and extreme sensitivity to bright light. This may be caused by an inflammation of the membranes that cover the brain and spinal cord (meningitis).Hearing impairment/hearing lossRinging in the ears (tinnitus)Vertigo (spinning sensation)You get a rash or skin discolouration with or without raised areas which often reoccurs at the same location each time the drug is taken
If you get any side effects, talk to your doctor, pharmacist or nurse. This includes any possible side effects not listed in this leaflet. You can also report side effects directly via the Yellow Card Scheme at: www.mhra.gov.uk/yellowcard or search for MHRA Yellow Card in the Google Play or Apple App Store.
By reporting side effects you can help provide more information on the safety of this medicine. Keep this medicine out of the sight and reach of children. Store below 30ºC in the original packaging in order to protect from light. Do not use this medicine after the expiry date which is stated on the pack after EXP.
The expiry date refers to the last day of that month. Do not throw away any medicines via wastewater or household waste. Ask your pharmacist how to throw away any medicines you no longer use. These measures will help protect the environment. Each tablet contains 400mg of metronidazole as the active substance.
Other ingredients are: calcium hydrogen phosphate (E341), starch maize, povidone K30 (E1201) and magnesium stearate. The coating of the tablets contains: Pharmacoat 615 (E464) and Macrogol 400. Flagyl 400mg Tablets are white to off-white biconvex film coated tablets with ‘FLAGYL 400′ printed on one side.
Flagyl 400mg Tablets are available in aluminium/plastic blister packs of 14 tablets and HDPE bottles of 100 tablets. Not all pack sizes may be marketed. Marketing Authorisation Holder Sanofi 410 Thames Valley Park Drive Reading Berkshire RG6 1PT UK Tel: 0800 035 2525 Manufacturer Famar Health Care Services Madrid, S.A.U.
- Avda. Leganés, 62 Alcorcón 28923 Madrid Spain Sanofi Aventis S.A. Ctra.
- C-35 (La Batlloria-Hostalric, Km.63.09) Riells I Viabrea 17404 Girona SPAIN This leaflet does not contain all the information about your medicine.
- If you have any questions or are not sure about anything, ask your doctor or pharmacist.
This leaflet was last revised in May 2023 © Sanofi, 1984 – 2023
Does Flagyl have side effects?
Page 7 -, /,,, muscle/,,,, or drowsiness may occur. If any of these effects last or get worse, tell your doctor or promptly. People using this may have serious side effects. However, you have been prescribed this drug because your doctor has judged that the benefit to you is greater than the risk of side effects.
Careful monitoring by your doctor may decrease your risk. Tell your doctor right away if you have any serious side effects, including: easy bruising/bleeding, unusual tiredness, sudden/, swelling hands//feet/, swelling around the, shortness of breath, fast heartbeat, black/, vomit that looks like coffee grounds, symptoms of (such as nausea/vomiting that doesn’t stop, loss of appetite, /, yellowing /, ).
This medication may lower your ability to fight infections. This may make you more likely to get a serious infection or make any infection you have worse. Tell your doctor right away if you have any signs of infection (such as that doesn’t go away, fever, chills).
- Sometimes causes side effects due to the rapid destruction of cells (tumor lysis syndrome).
- To lower your risk, drink plenty of fluids unless your doctor directs you otherwise.
- Also, your doctor may prescribe an additional medication.
- Tell your doctor right away if you have symptoms such as: low back/side pain (flank pain), signs of problems (such as, pink/bloody urine, change in the amount of urine), /.
Imatinib can commonly cause a that is usually not serious. However, you may not be able to tell it apart from a rare that could be a sign of a severe reaction. Get medical help right away if you develop any rash. A very serious to this drug is rare. However, get medical help right away if you notice any symptoms of a serious, including: rash, /swelling (especially of the face//throat), severe dizziness,,
This is not a complete list of possible side effects. If you notice any other effects not listed above, contact your doctor or pharmacist. In the US – Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch. In Canada – Call your doctor for medical advice about side effects.
You may report side effects to Health Canada at 1-866-234-2345. : Flagyl Oral: Uses, Side Effects, Interactions, Pictures, Warnings & Dosing
How quickly does metronidazole work?
How is metronidazole given? – Metronidazole is available as a capsule, tablet, and liquid suspension. It may also be compounded into a formulation (called metronidazole benzoate) that tastes less bitter and is easier to administer to cats. An injectable form is also available that your veterinarian will administer at your veterinary hospital.
Metronidazole should be given by mouth with food.” Metronidazole should be given by mouth with food. Liquid forms must be shaken well before use. Metronidazole is very bitter, so take care not to crush these tablets as it will be difficult to administer to your pet. Follow the dosing instructions provided by your veterinarian.
If you have difficulty administering the medication, contact your veterinary clinic for advice. This medication should take effect within one to two hours, and while effects may not be visibly noticed immediately, gradual improvements are usually noticeable after a few days.
How long does 500 mg of Flagyl stay in your system?
Even after your last dose of Flagyl, it remains in your system for some time. Flagyl may be cleared from your body within 48 hours, but the elimination rate varies depending on a person’s age and metabolism, among other factors.
Is 4 days of metronidazole enough?
Antibiotics – Trichomoniasis is usually treated quickly and easily with antibiotics, Most people are prescribed an antibiotic called metronidazole, which is very effective if taken correctly. You’ll usually have to take metronidazole twice a day, for 5 to 7 days.
- Sometimes this antibiotic can be prescribed in a single, larger dose.
- However, this may have a higher risk of side effects and it’s not recommended for pregnant or breastfeeding women as a precaution.
- Metronidazole can make you feel sick, be sick and cause a slight metallic taste in your mouth.
- It’s best to take it after eating food.
Contact your doctor for advice if you start vomiting, because the treatment will not be effective if you’re unable to swallow the tablets. Do not drink alcohol while taking metronidazole and for at least 24 hours after finishing the course of antibiotics.
a fast heartbeat or heart palpitationsskin flushingnausea and vomiting
A specialist can recommend alternative treatments if metronidazole is unsuitable for you (for example, if you’re allergic to it).
Can you have alcohol in food while taking metronidazole?
These include feeling and being sick, stomach pain, hot flushes, a pounding heartbeat (palpitations) and a headache. Is there any food or drink I need to avoid? You must not have any alcohol (in either your food or drink) while taking metronidazole, and for 2 days afterwards.
What STD does Flagyl treat?
This article focuses on vaginal infections, pelvic inflammatory disease and genital warts, with brief mention of proctitis, enteritis and ectoparasitic infections. It should be noted that vaginal candidiasis and bacterial vaginosis are included in the following discussion, although these infections are not sexually transmitted.
They are frequently diagnosed at the same time as sexually transmitted diseases (STDs), however, and the treatments often overlap. The three diseases that are most commonly associated with vaginitis are bacterial vaginosis, trichomoniasis and candidiasis. Diagnosis is based on pH measurement and microscopic examination of the vaginal discharge.
Symptoms of vaginitis include vaginal discharge, vulvar itching, or both, with or without vaginal odor. Vulvovaginal candidiasis is not transmitted sexually but is evaluated at the same time as screening for STDs. Bacterial vaginosis is the most common cause of vaginal discharge or malodor.
- It occurs when the normal flora of the vagina that produces Lactobacillus species is replaced with anaerobic bacteria.
- Bacterial vaginosis occurs more often in women who have multiple sexual partners, but it is not known if it is transmitted sexually.
- At this time, treatment for male sex partners is not recommended.
All women with symptomatic disease require treatment, including those who are pregnant. Studies have shown that bacterial vaginosis is associated with preterm delivery in pregnant women who are already at high risk for preterm delivery. Bacterial vaginosis is also associated with pelvic inflammatory disease, endometritis and vaginal cuff cellulitis after invasive procedures.
- A seven-day course of oral metronidazole (Flagyl) is recommended for the treatment of bacterial vaginosis.
- In addition, intravaginal clindamycin cream (Cleocin) and metronidazole gel (Metrogel) are recommended treatments in nonpregnant women.1 Table 1 shows treatment regimens that are approved for use in pregnant women.
Trichomoniasis is a disease associated with vaginal discharge that is caused by the protozoan Trichomonas vaginalis, Trichomoniasis is transmitted sexually, yet men usually remain asymptomatic. Trichomoniasis in women is characterized by a diffuse, malodorous, yellow-green discharge and vulvar irritation.
- As with bacterial vaginosis, vaginal trichomoniasis may be associated with adverse pregnancy outcomes.
- Trichomoniasis is treated with oral metronidazole (Flagyl).
- Topical metronidazole is not recommended.
- Table 1 shows treatment regimens in pregnant and nonpregnant women.
- Symptoms of vulvovaginal candidiasis include pruritis, vaginal discharge and, sometimes, vaginal soreness, vulvar burning, dyspareunia and external dysuria.
Vulvovaginal candidiasis can occur concomitantly with an STD or following antimicrobial therapy. Several topical agents are still recommended for the treatment of vulvovaginal candidiasis and are first-line therapies in pregnant women. An oral agent, fluconazole (Diflucan), has now been labeled for use in the treatment of vulvovaginal candidiasis.2, 3 Systemic effects, side effects and drug interactions must be considered when oral agents are used.
Is 500 mg of Flagyl a lot?
For bacterial and protozoal infections – Generic: Metronidazole
- Form: immediate-release oral tablet
- Strengths: 250 mg, 500 mg
- Form: immediate-release oral tablet
- Strengths: 250 mg, 500 mg
Adult dosage (ages 18–64 years) Your dosage and length of treatment depend on your infection type. Bacterial infections:
- Typical dosage: 500 mg two to four times per day for up to 14 days. However, some infections may require longer treatment.
- Maximum dosage: 4 g per day.
Typical dosage: 500 mg or 750 mg three times per day for 5–10 days.
Typical dosage: Either 2 grams (g) as a single dose or two divided doses of 1 g each on a single day, or 250 mg three times per day for 7 days.
Child dosage (ages 0–17 years) Amoebic infections:
Typical dosage: 35–50 mg/kg of body weight per day given in three divided doses for 10 days.
Senior dosage (ages 65 years and older) The kidneys and liver of older adults may not work as well as they used to. This can cause your body to process drugs more slowly. As a result, more of a drug stays in your body for longer. This increases your risk of side effects.
Is Flagyl 3 times a day?
Dosing – The dose of this medicine will be different for different patients. Follow your doctor’s orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.
For oral dosage forms (capsules or tablets):
For amebiasis infections:
Adults—500 or 750 milligrams (mg) 3 times a day for 5 to 10 days. Children—Dose is based on body weight and must be determined by your doctor. The dose is usually 35 to 50 milligrams (mg) per kilogram (kg) of body weight per day, divided into 3 doses, for 10 days.
For bacterial infections:
Adults—Dose is based on body weight and must be determined by your doctor. The dose is usually 7.5 milligrams (mg) per kilogram (kg) of body weight every 6 hours for 7 to 10 days. Your doctor may increase your dose as needed. However, the dose is usually not more than 4000 mg per day. Children—Use and dose must be determined by your doctor.
For trichomoniasis infections:
Adults—The tablet can be given 3 different ways: as a single dose of 2 grams, as 1 gram 2 times a day for 1 day, or as 250 milligrams (mg) 3 times a day for 7 days. The capsule dose is 375 mg 2 times a day for 7 days. Children—Use and dose must be determined by your doctor.
For oral dosage form (extended-release tablets):
For bacterial vaginosis:
Adults—750 milligrams (mg) once a day for 7 days. Children—Use and dose must be determined by your doctor.
What not to mix with Flagyl?
While taking metronidazole and for 3 days after your last dose: Do not drink alcohol or consume foods, medicines, or other products that contain alcohol or propylene glycol. You may have unpleasant effects such as headaches, nausea, vomiting, stomach cramps, and warmth or tingling under your skin.
Can I eat yogurt with metronidazole?
Precautions – Drug information provided by: Merative, Micromedex ® It is very important that your doctor check your progress at regular visits for any problems or unwanted effects that may be caused by this medicine. Do not use this medicine if you are also using methoxyflurane or have used disulfiram in the last 2 weeks.
- Do not drink alcohol while you are using this medicine and for at least 3 days after your last dose.
- Using this medicine while you are pregnant can harm your unborn baby.
- Use an effective form of birth control to keep from getting pregnant.
- If you think you have become pregnant while using this medicine, tell your doctor right away.
Birth control pills may not work properly if you take them while you are using this medicine. You should use a different or additional means of birth control (eg, condoms, diaphragm, or a contraceptive foam or jelly) while you are using this medicine.
If you have any questions about this, check with your doctor. Bismuth subcitrate may cause your tongue to become a darker color or even black. It may also make your stools (bowel movements) black. This is only temporary and will not hurt you. Your tongue and stools will go back to normal when you stop using this medicine.
Ask your doctor about this if you have any concerns. Do not drink milk or eat dairy products with this medicine. Check with your doctor right away if you start to have a stiff neck, drowsiness, fever, severe headache, nausea, vomiting, painful eye movements, or eye sensitivity to light.
These could be symptoms of a serious condition called aseptic meningitis syndrome (AMS). Check with your doctor right away if you are having burning, numbness, tingling, or painful sensations in the arms, hands, legs, or feet. These could be symptoms of a condition called peripheral neuropathy. Tetracycline may make your skin more sensitive to sunlight.
Exposure to sunlight, even for brief periods of time, may cause a rash, itching, redness, or other discoloration of the skin, or a severe sunburn. Use a sunscreen when you are outdoors. Avoid sunlamps and tanning beds. Serious skin reactions, including Stevens-Johnson syndrome, toxic epidermal necrolysis, and drug reaction with eosinophilia and systemic symptoms (DRESS) can occur with this medicine.
Check with your doctor right away if you have black, tarry stools, blistering, peeling, or loosening of the skin, chest pain, chills, cough, diarrhea, fever, itching, painful or difficult urination, red irritated eyes, red skin lesions, severe acne or skin rash, sore throat, sores or ulcers or white spots in the mouth or on the lips, swollen glands, or unusual tiredness or weakness while you are using this medicine.
Before you have any medical tests or x-rays, tell the medical doctor in charge that you are using this medicine. The results of some tests may be affected by this medicine. You should not drink alcoholic beverages or take other alcohol-containing preparations while you are using this medicine, and for at least 1 day after stopping it.
What happens if you eat chocolate with metronidazole?
Food and Drug Interactions You Need to Know About If you’re one of the millions of Americans who take a such as atorvastatin (Lipitor and generic) or simvastatin (Zocor and generic) to lower your cholesterol, you may have been told to, That’s because the juice can intensify the strength of these common drugs and increase the chance of side effects—notably, muscle pain.
|Type of Food||Don’t Mix With||The Reason|
|Bananas, green leafy vegetables, oranges, salt substitutes||ACE inhibitors such as captopril (Capoten), enalapril (Vasotec), and lisinopril (Prinivil, Zestril), used to lower blood pressure or treat heart failure. And avoid mixing with some diuretics, such as triamterene (Dyrenium), used to reduce fluid retention and treat high blood pressure.||These foods are all high in potassium, which helps provide electrical signals to heart-muscle cells and other cells. Consuming them with the medications listed to the left could increase the amount of potassium in your body and may lead to an irregular heartbeat or heart palpitations—which could be deadly.|
|Broccoli, Brussels sprouts, cabbage, kale, spinach||such as warfarin (Coumadin).||Foods that contain a lot of vitamin K, such as the greens noted on the left, can reduce the drugs’ ability to thin the blood. In some people with heart disease, that could trigger a heart attack or a stroke. Once you begin taking warfarin, maintain a consistent diet and don’t suddenly overload on leafy greens.|
|Real black licorice (or supplements with licorice extract)||Digoxin (Lanoxin), used to treat and abnormal heart rhythms. It’s also best not to consume with most blood pressure drugs, blood thinners, and birth-control pills.||Real black licorice (and products with licorice extract, as opposed to licorice-flavored candy) contain glycyrrhizin, which can cause an irregular heartbeat, or even death, when combined with digoxin. Glycyrrhizin may reduce the effectiveness of most blood pressure drugs, intensify the side effects of blood thinners, and raise blood pressure and lower potassium levels when consumed with birth-control pills.|
|Cheese, yogurt, milk, calcium supplements, antacids with calcium||Tetracycline.||The calcium in these foods and products can interfere with the body’s ability to absorb the antibiotic fully. In general, tetracycline works better if taken 1 hour before or 2 hours after eating.|
|Alcohol, avocados, bananas, chocolate, salami||Drugs such as metronidazole (Flagyl) and linezolid (Zyvox), used to treat bacterial infections.||The foods to the left, along with tap beer, red wine, and sherry, contain tyramine, an amino acid that can cause blood pressure to spike if taken with linezolid. Tyramine is also found in foods that are aged, pickled, fermented, or smoked, such as processed cheeses, anchovies, and dry sausage. Alcohol and metronidazole together could cause nausea, stomach cramping, and vomiting.|
|Soybean flour, walnuts||Thyroid drugs such as levothyroxine (Levothroid, Levoxyl, Synthroid).||These high-fiber foods can prevent your body from absorbing the medications. If you eat a high-fiber diet, try taking your medications later in the evening. One study found that the drugs were better absorbed when taken at bedtime rather than a half-hour before breakfast, which is what is usually recommended in the instructions.|
Editor’s Note: This article also appeared in the December 2017 issue of, : Food and Drug Interactions You Need to Know About
How long does it take to get metronidazole out of your system?
Official answer – by Drugs.com It will take about 44 hours (5.5 x elimination half life 8 hrs) for metronidazole to be cleared from your system. The elimination half life of metronidazole is approximately 8 hours. It takes 5.5 x elimination half life for a medicine to be completely cleared from the body.
How common is disulfiram reaction with metronidazole?
Sir, we are writing to draw attention to some interesting research that questions the validity of the disulfiram-like reaction between metronidazole and alcohol. This reaction is the reason the British National Formulary 1 advises to avoid alcohol during and for 48 hours after taking metronidazole.
- Giving this advice is standard practice amongst most clinicians.
- Disulfiram is a drug used to discourage alcohol consumption.
- Its interaction with alcohol leads to acetaldehyde accumulation causing symptoms such as skin redness, palpitations, nausea, vomiting, headache and in severe cases circulatory collapse.2 The disulfiram-like reaction of metronidazole and alcohol is said to be similar, and was traditionally explained by the same mechanism, although this now seems to be incorrect.2, 3, 4 Its frequency is unclear as figures vary between 0 and 100%.5 Its validity has been repeatedly questioned in the modern literature.
Serious reactions including at least one death have been attributed to it, 3, 5 although at least some of these have been disputed.3 A number of clinical studies and reviews have found evidence of the existence of this interaction to be absent or weak.2, 3, 4, 6 Although we do not seek to promote alcohol intake, the advice to abstain completely will restrict patient lifestyle for that period.
There are situations such as alcohol dependent patients where this could be especially problematic, so settling this is important. Overall the evidence for this reaction appears to be weak at best. It appears likely that the concern attached to it is overstated. The purported reaction could actually be an alcohol-independent side effect of metronidazole, an effect of alcohol, or disease – possibilities not adequately eliminated by the studies.2 Furthermore, the term ‘disulfiram-like’ is a misnomer, at least in a biochemical sense, as it seems that any such reaction does not occur through the same mechanism as disulfiram.
Conversely, no definite evidence is presented that this reaction does not occur – perhaps it occurs only in a small subgroup. The aim of this letter is not to suggest we, as clinicians, stop advising patients to avoid alcohol whilst on metronidazole. Rather all clinicians should be alert to its weak evidence base and be ready to question and reject long-held beliefs and mantras such as this should new evidence emerge.